The relationship between serum levels of anti-cyclic citrullinated peptide antibodies and disease activity in patients with rheumatoid arthritis

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dc.contributor.authorDeveci, Köksal
dc.contributor.authorDeveci, Hülya
dc.contributor.authorBayram, Korhan Barïş
dc.contributor.authorKoçyi?it, Hikmet
dc.contributor.authorGürgan, Alev
dc.date.accessioned2024-10-26T17:53:01Z
dc.date.available2024-10-26T17:53:01Z
dc.date.issued2012
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: Although there is an opinion that anti-cyclic citrullinated peptide antibody (anti-CCP) is a reliable diagnostic and prognostic indicator in rheumatoid arthritis (RA), its association with disease activity and severity is uncertain. This study has been planned to determine the relationship between anti-CCP antibody levels and the disease activity in patients with RA. Materials and Methods: A total of 48 patients, who have been diagnosed with RA, were included in the study. After physical examination, all patients were evaluated with clinical and laboratory parameters. The clinical symptoms were assessed using visual analog scale (VAS), disease activity score (DAS-28) and Health Assessment Questionnaire (HAQ). Rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), thrombocyte, leukocyte, hemoglobin and anti-CCP levels were investigated. Results: The anti-CCP results were positive in 33 patients (68.7%) and negative in 15 patients (31.3%). Anti-CCP was positive in 30.4% of RF negative patients. A significant difference was observed in average RF levels when the anti-CCP positive and negative patients were compared, however, there was no significance between other parameters. In logistic regression analysis of multiple parameters, higher DAS-28 scores and RF positivity were associated with 5.95 and 5.4 times greater risk of being anti-CCP positive, respectively. Conclusion: Anti-CCP can be used in the diagnosis of patients with seronegative RA and also may be useful for reflecting disease activity. © Turkish Journal of Physical Medicine and Rehabilitation, Published by Galenos Publishing.
dc.identifier.doi10.4274/tftr.16769
dc.identifier.endpage271
dc.identifier.issn1302-0234
dc.identifier.issue4
dc.identifier.scopus2-s2.0-84872201882
dc.identifier.scopusqualityN/A
dc.identifier.startpage267
dc.identifier.urihttps://doi.org/10.4274/tftr.16769
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26669
dc.identifier.volume58
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTurkish Society of Physical Medicine and Rehabilitation
dc.relation.ispartofTurkiye Fiziksel Tip ve Rehabilitasyon Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnti-CCP antibodies; Disease activity; Rheumatoid arthritis; Rheumatoid factor
dc.titleThe relationship between serum levels of anti-cyclic citrullinated peptide antibodies and disease activity in patients with rheumatoid arthritis
dc.title.alternativeRomatoid artritli hastalarda serum anti-cyclic citrullinated peptid antikor düzeyleri ve hastalık aktivitesi arasındaki i?lişki
dc.typeArticle

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