Investigation on Antimicrobial Resistance Levels of Escherichia coli Strains Isolated from Bovine Fecal Samples and Comparison with Guidelines of the Clinical Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST)

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dc.contributor.authorKalın, Recep
dc.contributor.authorKaragülle, Burcu
dc.contributor.authorAçık, Mehmet Nuri
dc.contributor.authorKarahan, Murat
dc.contributor.authorÖztürk, Yasin
dc.contributor.authorÇetinkaya, Burhan
dc.date.accessioned2024-10-26T17:41:00Z
dc.date.available2024-10-26T17:41:00Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractThis study was carried out to investigate the antibiotic resistance levels of Escherichia coli isolates of bovine origin and to compare the results with CLSI and EUCAST guideline values. For this purpose, 97 E. coli strains isolated from fecal samples of cattle in 12 different farms were tested against 32 antibiotics by using the disk diffusion method. The zone diameters of 13 antibiotics examined within the scope of the study were compared according to the CLSI and EUCAST 2020 guidelines, and their consistency levels were evaluated statistically. The highest resistance rates in E. coli isolates were determined against tetracycline (68%), streptomycin (63.9%), ampicillin (58.8%), and doxycycline (50.5%) antibiotics. On the other hand, the isolates were found to be highly susceptible to amikacin and cephalosporin group antibiotics. When CLSI and EUCAST guidelines were compared, it was found that there were statistically significant differences between the resistance rates of nitrofurantoin, gentamicin, and amikacin. Only 10 (10.3%) of the isolates were detected to be susceptible to all the antibiotics tested, whereas 17.5% were resistant to 10 or more antibiotics. The results of this study showed that E. coli isolates of bovine origin were highly resistant against antibiotics used in the field for a long period, especially the number of isolates with multiple antibiotic resistance was striking. It was concluded that due to substantial inconsistencies between the CLSI and EUCAST guidelines for some antibiotics such as amikacin, nitrofurantoin, and gentamicin, there is an urgent need to execute necessary updates in both guidelines.
dc.identifier.doi10.30607/kvj.1302078
dc.identifier.endpage341
dc.identifier.issn1308-1594
dc.identifier.issn2147-6853
dc.identifier.issue3
dc.identifier.startpage334
dc.identifier.trdizinid1204640
dc.identifier.urihttps://doi.org/10.30607/kvj.1302078
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1204640
dc.identifier.urihttps://hdl.handle.net/20.500.12418/24241
dc.identifier.volume16
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKocatepe Veterinary Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEscherichia coli
dc.subjectBovine
dc.subjectAntibiotic resistance
dc.subjectCLSI
dc.subjectEUCAST
dc.titleInvestigation on Antimicrobial Resistance Levels of Escherichia coli Strains Isolated from Bovine Fecal Samples and Comparison with Guidelines of the Clinical Laboratory Standards Institute (CLSI) and European Committee on Antimicrobial Susceptibility Testing (EUCAST)
dc.typeArticle

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