Does dietary intake of acrylamide affect hydroxyproline levels? an animal study

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dc.contributor.authorAgbektas, Tugba
dc.contributor.authorPazarcı, Özhan
dc.contributor.authorTaş, Ayça
dc.contributor.authorÇakmak, Neşe Keklikcioğlu
dc.contributor.authorKılınç, Seyran
dc.contributor.authorSiliğ, Yavuz
dc.date.accessioned2024-10-26T17:44:03Z
dc.date.available2024-10-26T17:44:03Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAcrylamide is a chemical that occurs due to high temperatures during cooking. It consists of an amino acid found in foods and sugars. Studies have shown that cancer formation occurs within the scope of oxidant reagents and DNA damage due to exposure to acrylamide. Our study aims to examine the effects of dietary acrylamide intake on plasma hydroxyproline levels in rats. In this study, 4 groups were formed with 8 rats in each group (total number=32). Blood samples were collected on days 14 and 28. Acrylamide solution was applied to each rat in the treatment group by gastric gavage process at 5 mg/kg three times a week. Hydroxyproline levels in rats’ plasma samples were measured. The median (IQR) hydroxyproline levels were 7.40(2.45) ?g/L in group 1 (14. days control group) and 7.98(3.34) ?g/L in group 2 (14. days acrylamide applied) who received acrylamide. The mean hydroxyproline levels were 7.25(1.96) ?g/L in group 3 (28. days control group) and 9.76(2.64) ?g/L in group 4 (28. days acryl- amide applied) who received acrylamide. No difference was observed between the groups. Dietary acrylamide intake did not have a significant effect on hydroxyproline levels at the application dose and duration in our study.
dc.identifier.doi10.5455/medscience.2022.04.082
dc.identifier.endpage1481
dc.identifier.issn2147-0634
dc.identifier.issue4
dc.identifier.startpage1478
dc.identifier.trdizinid1168072
dc.identifier.urihttps://doi.org/10.5455/medscience.2022.04.082
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1168072
dc.identifier.urihttps://hdl.handle.net/20.500.12418/25084
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofMedicine Science
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleDoes dietary intake of acrylamide affect hydroxyproline levels? an animal study
dc.typeArticle

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