EFFECT OF LOCAL RIFAMYCIN APPLICATION ON EXPRESSION OF BMP-2 AND BONE REGENERATION

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dc.contributor.authorÖzeç, Emin Ün1 İlker
dc.contributor.authorTaşdemİr, Ufuk
dc.contributor.authorKirtay, Mustafa
dc.contributor.authorEsen, Hacı Hasan
dc.contributor.authorAvunduk, Mustafa Cihat
dc.date.accessioned2024-10-26T17:53:09Z
dc.date.available2024-10-26T17:53:09Z
dc.date.issued2017
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjectives: The aim of this study was to evaluate effect of local rifamycin application on BMP-2 expression and bone healing. Materials and Methods: A standardized 5.0-mm-diameter critical size bone defect was created mandible angulus region. In the control group (8 rats) defects were left empty. In the Group 1 (n=8 rats) defect was irrigated with rifamycin solution and 25 mg rifamycin solution injected defect area at 1, 3, 7 days after surgery. In the group 2 (n=8 rats) defects were grafted with a gelatin sponge mixed 25 mg rifamycin solution. Rats were sacrificed at 21 days after surgery. Histological slides were prepared from defect site for both immunohistochemical analysis (bone morphogenetic protein-2 (BMP-2) antibody) and histomorphometric analysis. Data were analyzed using Mann Whitney U and Kruskall Wallis test. Results: The average new bone formation, number of osteoblast and new vessel formation count were increased more in both of experimental groups in comparison with control group. Anti-BMP-2 labelling (Cell count) was increased more in both of experimental groups in comparison with control group. Conclusion: Local rifamycin application has positive effects on BMP-2 expression and bone regeneration at critical sized bone defects. © 2017. Cumhuriyet Dental Journal. All Rights Reserved.
dc.description.sponsorshipSivas Cumhuriyet Üniversitesi, (DİŞ-108)
dc.identifier.doi10.7126/CUMUDJ.345934
dc.identifier.endpage105
dc.identifier.issn2146-2852
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85122996353
dc.identifier.scopusqualityQ4
dc.identifier.startpage98
dc.identifier.urihttps://doi.org/10.7126/CUMUDJ.345934
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26761
dc.identifier.volume20
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherCumhuriyet University Faculty of Dentistry
dc.relation.ispartofCumhuriyet Dental Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBone morphogenetic protein – 2; Bone regeneration; Critical sized bone defect; Rifamycin
dc.titleEFFECT OF LOCAL RIFAMYCIN APPLICATION ON EXPRESSION OF BMP-2 AND BONE REGENERATION
dc.title.alternativeYerel Rifamicin Uygulamasının Bmp-2 ve Kemik Rejenerasyon Açısından Etkisi
dc.typeArticle

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