Investigation of Interactions Between Tetracycline Antibiotics and Bromelain Enzyme Using Docking Tools

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dc.contributor.authorAylaz, Gülgün
dc.date.accessioned2024-10-26T17:38:03Z
dc.date.available2024-10-26T17:38:03Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBromelain, extracted from the stem of the pineapple, is a complex enzyme used for different purposes. Bromelain supplements are often used to facilitate digestion, improve the circulatory system and relieve arthritis symptoms due to its pain relief. However, in some cases where there is a risk of antibiotic use or bleeding, the use of bromelain or direct consumption of pineapple should be limited. For this purpose, this study was carried out to show the mechanism by which the antibiotic bromelain interaction occurs. Firstly, the bromelain molecule and demeclocycline, minocycline, and tetracycline antibiotics were prepared in the UCSF Chimera visualizing program. The interactions were monitored in the Auto Dock Molecular Modelling Toolkit molecular modeling program. The free binding energies of these interactions were also calculated in Auto Dock. According the molecular modelling results, bromelain and demeclocycline, minocycline, tetracycline antibiotics were interact with hydrogen bonds and hydrophobic interactions. These interactions between bromelain and antibiotics were energetically favorable based on free binding energy calculations.
dc.identifier.doi10.21597/jist.1306563
dc.identifier.endpage2996
dc.identifier.issn2146-0574
dc.identifier.issn2536-4618
dc.identifier.issue4
dc.identifier.startpage2986
dc.identifier.trdizinid1211201
dc.identifier.urihttps://doi.org/10.21597/jist.1306563
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1211201
dc.identifier.urihttps://hdl.handle.net/20.500.12418/23799
dc.identifier.volume13
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofIğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMolecular docking
dc.subjecttetracycline
dc.subjectBromelain
dc.subjectdemeclocycline
dc.subjectminocycline
dc.titleInvestigation of Interactions Between Tetracycline Antibiotics and Bromelain Enzyme Using Docking Tools
dc.typeArticle

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