The Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats

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dc.contributor.authorÇiltaş, Arzuhan Çetindağ
dc.contributor.authorÖztürk, Ayşegül
dc.date.accessioned2024-10-26T17:42:46Z
dc.date.available2024-10-26T17:42:46Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractEpilepsyisadiseasewhichcausesneuronaldamageandlossofconsciousnessin consequence of recurrent seizures. Nitric oxide as a neuromodulator in brain is a gas which can penetrate into cells. It has a significant role on physiological cases,pathology of many diseases suchasinflammationanddegenerativediseases.Thepurposeofthisresearchistosearchthe activity of NO/cGMP pathway of valproic acid in an experimental acuteepileptic model which is induced with pentylenetetrazol in rats.18 adult male Wistar Albino rats were used in the study. Theratswererandomlydividedinto3groups(n=6)ascontrolgroup,pentylenetetrazol (PTZ+salin)45mgkg-1,valproicacid(PTZ+VPA)150mgkg-1.After24hoursofPTZ application, all rats brain tissues were removed and then cortex and hippocampus were separated. WhilePTZincreasedthehippocampusandcortexNO/cGMPlevelscomparedtocontrol(p <0.01),VPAdecreasedthehippocampusandcortexNOlevelsbycomparisonwithPTZ(p <0.001). On the other hand, while VPA decreased cortex cGMP levels (p<0,05) it did not change cGMP levels in hippocampus (p> 0.05). This study has suggested that VPA can show antiepileptic activity via NO/cGMP pathway.
dc.identifier.doi10.46810/tdfd.882078
dc.identifier.endpage10
dc.identifier.issn2149-6366
dc.identifier.issue1
dc.identifier.startpage6
dc.identifier.trdizinid1069518
dc.identifier.urihttps://doi.org/10.46810/tdfd.882078
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1069518
dc.identifier.urihttps://hdl.handle.net/20.500.12418/24802
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTürk Doğa ve Fen Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectEpilepsy
dc.subjectPentylenetetrazole
dc.subjectNO/cGMP
dc.subjectValproin Acid
dc.titleThe Effects of Valproic Acid on NO/cGMP in Pentylenetetrazole-Induced Acut Epilepsy Model in Rats
dc.typeArticle

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