Protective Effects of Lactobacillus plantarum Exopolysaccharides from Home Made Dairy Products on Obesity

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dc.contributor.authorDemir, Ahmet Turan
dc.contributor.authorÇadırcı, Bilge Hilal
dc.contributor.authorAltun, Ahmet
dc.date.accessioned2025-05-04T16:26:30Z
dc.date.available2025-05-04T16:26:30Z
dc.date.issued2022
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAs it is known, obesity is one of the most important health problems of developed and developing countries today. Obesity; endocrine, cardiovascular, respiratory, gastrointestinal (GI), genitourinary, musculoskeletal system such as body systems and psychosocial condition causes many health problems due to the negative effects. The ability of probiotics to support GI health has been recognized for years. Since alternative approaches against obesity can be developed by intervention in the GI system, this study aimed to evaluate the effects of exopolysaccharides (EPS) as an anti-obesity biomaterial isolated from natural products with probiotic characteristics. First, the one with the highest EPS amount among the 10 microorganisms with known probiotic properties was identified by MALDI-TOF and 16s rRNA sequence analysis and named as Lactobacillus plantrum BHC007. Then, the monosaccharide composition of the extracted EPS was examined, and its average molecular weight was determined as 221.860±0.006. The effect of EPS on the adipogenesis process was examined qualitatively with Oil Red O dye on the 3T3 cell line and cellular triacylglycerol (TAG) levels. It was concluded that the highest EPS concentration (2.25 mM) inhibited adipogenesis by 75%. Also, 17% inhibition of adipogenesis was achieved at the lowest EPS concentration (0.45 mM). In conclusion, TAG analysis revealed that EPS was suppressed depending on the lipid droplet formation concentration.
dc.description.abstract[No abstract available]
dc.identifier.doi10.7197/cmj.1156620
dc.identifier.doihttps://doi.org/10.7197/cmj.1156620
dc.identifier.endpage281
dc.identifier.issn1305-0028
dc.identifier.issue3
dc.identifier.startpage273
dc.identifier.urihttps://hdl.handle.net/20.500.12418/32752
dc.identifier.volume44
dc.language.isoen
dc.publisherSivas Cumhuriyet University
dc.relation.ispartofCumhuriyet Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20250504
dc.subjectExopolysaccharide
dc.subjectprobiotic
dc.subjectobesity
dc.titleProtective Effects of Lactobacillus plantarum Exopolysaccharides from Home Made Dairy Products on Obesity
dc.typeResearch Article

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