In Vitro Antidiabetic, Antiinflammatory, Cytotoxic, Antioxidant and Antimicrobial Activities of Pomegranate (Punica granatum L.) Peel

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dc.contributor.authorDemir, Tuğba
dc.contributor.authorAkpınar, Özlem
dc.contributor.authorKara, Haki
dc.contributor.authorGüngör, Hüseyin
dc.date.accessioned2024-10-26T17:52:49Z
dc.date.available2024-10-26T17:52:49Z
dc.date.issued2019
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractIn this study, antioxidant, antimicrobial, antidiabetic, antiinflammatory and cytotoxic properties of the pomegranate (Punica granatum L.) peel were investigated. The composition of the phenolic compounds of the pomegranate peel extract (33%, 78°C, 113 min) was determined and it was found to contain high amounts of punigalagin, caffeic acid and epicatechin. At the same time, the extract was found to have high antioxidant capacity. It showed antimicrobial activity against selected microorganisms (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Aspergillus flavus and Aspergillus niger) and its highest microbial resistance was found to be against S. aureus (21 mm; 1.87 mg extract /mL). It inhibited ?-amylase and ?-glucosidase enzymes and showed the antidiabetic property. At the same time, the extract was able to inhibit xanthine oxidase and lipoxygenase enzymes that were responsible for the inflammation and its cytotoxic activity on breast and bone cancer cells were also observed. It was concluded that pomegranate peel extracts could be used in food and non-food applications due to its biological activities. © 2017 The authors.
dc.identifier.doi10.24323/AKADEMIK-GIDA.544647
dc.identifier.endpage71
dc.identifier.issn1304-7582
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85089090138
dc.identifier.scopusqualityQ4
dc.identifier.startpage61
dc.identifier.urihttps://doi.org/10.24323/AKADEMIK-GIDA.544647
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26533
dc.identifier.volume17
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherSidas Medya A.S.
dc.relation.ispartofAkademik Gida
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAntidiabetic; Antiinflammatory; Antimicrobial; Cytotoxic; Pomegranate peel
dc.titleIn Vitro Antidiabetic, Antiinflammatory, Cytotoxic, Antioxidant and Antimicrobial Activities of Pomegranate (Punica granatum L.) Peel
dc.title.alternativeNar (Punica granatum L.) Kabuğunun İn Vitro Antidiyabetik, Antienflamatuar, Sitotoksik, Antioksidan ve Antimikrobiyal Aktivitesi
dc.typeArticle

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