Plasma osmolality predicts mortality in patients with heart failure with reduced ejection fraction

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dc.authoridKaya, Hakki/0000-0001-5230-635X
dc.authoridYilmaz, Mehmet Birhan/0000-0002-8169-8628
dc.contributor.authorKaya, Hakki
dc.contributor.authorYucel, Oguzhan
dc.contributor.authorEge, Meltem Refiker
dc.contributor.authorZorlu, Ali
dc.contributor.authorYucel, Hasan
dc.contributor.authorGunes, Hakan
dc.contributor.authorEkmekci, Ahmet
dc.date.accessioned2024-10-26T18:09:55Z
dc.date.available2024-10-26T18:09:55Z
dc.date.issued2017
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: Heart failure (HF) is a fatal disease. Plasma osmolality with individual impacts of sodium, blood urea nitrogen (BUN), and glucose has not been studied prognostically in patients with HF. Aim: This study aims to investigate the impact of serum osmolality on clinical endpoints in HF patients. Methods: A total of 509 patients (383 males, 126 females) with HF with reduced ejection fraction in three HF centres were retrospectively analysed between January 2007 and December 2013. Follow-up data were completed for 496 patients. Plasma osmolality was calculated as (2 x Na) + (BUN/2.8) + (Glucose/18). Quartiles of plasma osmolality were produced, and the possible relationship between plasma osmolality and cardiovascular mortality was investigated. Results: The mean follow-up was 25 +/- 22 months. The mean age was 56.5 +/- 17.3 years with a mean EF of 26 +/- 8%. The mean levels of plasma osmolality were as follows in the quartiles: 1st % = 280 +/- 6, 2nd % = 288 +/- 1, 3rd % = 293 +/- 2 (95% confidence interval [ CI] 292.72-293.3), and 4th % = 301 +/- 5 mOsm/kg. The EF and B-type natriuretic peptide levels were similar in the four quartiles. Univariate and multivariate analyses in the Cox proportional hazard model revealed a significantly higher rate of mortality in the patients with hypo-osmolality. The Kaplan-Meier plot showed graded mortality curves with the 1st quartile having the worst prognosis, followed by the 4th quartile and the 2nd quartile, while the 3rd quartile was shown to have the best prognosis. Conclusions: Our study results suggest that normal plasma osmolality is between 275 and 295 mOsm/kg. However, being close to the upper limit of normal range (292-293 mOsm/kg) seems to be the optimal plasma osmolality level in terms of cardiovascular prognosis in patients with HF.
dc.identifier.doi10.5603/KP.a2016.0168
dc.identifier.endpage322
dc.identifier.issn0022-9032
dc.identifier.issn1897-4279
dc.identifier.issue4
dc.identifier.pmid27958615
dc.identifier.startpage316
dc.identifier.urihttps://doi.org/10.5603/KP.a2016.0168
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30346
dc.identifier.volume75
dc.identifier.wosWOS:000399748200003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVia Medica
dc.relation.ispartofKardiologia Polska
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectheart failure
dc.subjectosmolality
dc.subjectmortality
dc.titlePlasma osmolality predicts mortality in patients with heart failure with reduced ejection fraction
dc.typeArticle

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