Relationship between serum cystatin C level and M694V homozygosity in patients with familial Mediterranean fever

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dc.authoridSAHIN, ALI/0000-0002-6953-4276
dc.authoridakan, selcuk/0000-0002-5053-6896
dc.contributor.authorErzurum, Cahide
dc.contributor.authorErten, Sukran
dc.contributor.authorAkan, Selcuk
dc.contributor.authorSahin, Ali
dc.contributor.authorIsikoglu, Semra
dc.contributor.authorErel, Ozcan
dc.date.accessioned2024-10-26T18:07:44Z
dc.date.available2024-10-26T18:07:44Z
dc.date.issued2020
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractAim: In this study we aimed to evaluate the relation of cystatin C with proteinuria, estimated glomerular filtration rate (eGFR), and disease activity in patients with familial Mediterranean fever (FMF). Material and Methods: One hundred twenty four patients with FMF and 66 healthy controls were included in the study. Complete blood count (CBC), acute phase reactants (erythrocyte sedimentation rate, c-reactive protein), routine biochemical tests, thyroid function tests (TFT), FMF gene analysis, 24-hour urine analysis and serum cystatin C levels were evaluated. Results: Patients and controls had similar cystatin C levels. A significant negative relationship between creatinine clearance and cystatin C, and a significant positive relationship between microalbuminuria and cystatin C were detected (p=0.008 and p=0.005, respectively) in FMF patients. Cystatin C levels were significantly higher in M694V homozygotes than in M694V mutation-negative patients (p=0.016). Cystatin C levels were higher in men than in women in FMF and control groups (p=0.008, and p=0.003, respectively). Discussion: In accordance with the literature, creatinine clearance and microalbuminuria were found to be related to serum cystatin C levels. Therefore, cystatin C or cystatin C-based eGFR measurement is important for early detection of nephropathy and early treatment of the disease.
dc.identifier.doi10.4328/ACAM.20188
dc.identifier.endpage264
dc.identifier.issn2667-663X
dc.identifier.startpage260
dc.identifier.urihttps://doi.org/10.4328/ACAM.20188
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29667
dc.identifier.volume11
dc.identifier.wosWOS:000572739700023
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBayrakol Medical Publisher
dc.relation.ispartofAnnals of Clinical and Analytical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFMF
dc.subjectSerum Cystatin C
dc.subjectProteinuria
dc.subjectGFR
dc.titleRelationship between serum cystatin C level and M694V homozygosity in patients with familial Mediterranean fever
dc.typeArticle

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