Oral ulcer activity assessment with the composite index according to different treatment modalities in Behcet's syndrome: a multicentre study

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dc.authoridTecer, Duygu/0000-0002-8816-6181
dc.authoridYay, Meral/0000-0003-1857-8719
dc.authoridCinar, Muhammet/0000-0002-6150-3539
dc.authoridaksu, kenan/0000-0001-8889-2688
dc.authoridsahin, ali/0000-0003-0743-5288
dc.authoridKaradag, Omer/0000-0002-3443-3117
dc.authoridBadak, Suade ozlem/0000-0002-4661-787X
dc.contributor.authorMumcu, G.
dc.contributor.authorKaracayli, U.
dc.contributor.authorYay, M.
dc.contributor.authorAksoy, A.
dc.contributor.authorTas, M. N.
dc.contributor.authorArmagan, B.
dc.contributor.authorSari, A.
dc.date.accessioned2024-10-26T18:11:43Z
dc.date.available2024-10-26T18:11:43Z
dc.date.issued2019
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective. The aim of this multicentre study was to understand patients' needs and to evaluate the oral ulcer activity with the Composite Index (CI), according to different treatment modalities in Behcet's syndrome (BS). Methods. BS patients (n=834) from 12 centres participated in this cross-sectional study. Oral ulcer activity (active vs. inactive) and the CI (0: inactive vs. 1-10 points: active) were evaluated during the previous month. The effects of treatment protocols [non-immunosuppressive: non-IS vs. immunosuppressive: (ISs)], severity (mild vs. severe), disease duration (<5 years vs. >= 5 years) and smoking pattern (non-smoker vs. current smoker) were analysed for oral ulcer activity. Results. Oral ulcer activity was observed in 65.1% of the group (n=543). In both genders, the activity was higher in mild disease course with non-IS treatment group compared to severe course with ISs (p<0.05). As a resistant group, patients with mild disease course whose mucocutaneous symptoms were unresponsive to non-IS medications were treated with ISs in a limited period and achieved the highest CI scores in females. Oral ulcer activity and poor CI score were associated with disease duration less than 5 years compared to others in male patients (p<0.05). Conclusion. Oral ulcer activity pattern is affected by both the combination of disease course, treatment protocols and disease duration. CI scores reflected the oral clinical activity and CI might be a candidate scale to evaluate the efficacy of treatments during the follow-up of oral ulcer activity in BS.
dc.identifier.endpage104
dc.identifier.issn0392-856X
dc.identifier.issn1593-098X
dc.identifier.issue6
dc.identifier.pmid31856935
dc.identifier.startpage98
dc.identifier.urihttps://hdl.handle.net/20.500.12418/30782
dc.identifier.volume37
dc.identifier.wosWOS:000501598300015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherClinical & Exper Rheumatology
dc.relation.ispartofClinical and Experimental Rheumatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOral ulcer
dc.subjectBehcet's syndrome
dc.subjecttreatment
dc.subjectcomposite index
dc.subjectgender
dc.titleOral ulcer activity assessment with the composite index according to different treatment modalities in Behcet's syndrome: a multicentre study
dc.typeArticle

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