Investigating the Healing Effect of Hyperici Oleum and Triticum vulgare on Septal Perforation in Rats: A Preliminary Study

Objective: The aim of this study was to investigate histopathologically the possible beneficial effects of hyperici oleum and Triticum vulgare, having anti-inflammatory, antioxidant, and antiproliferative properties, on the healing process of nasal septum perforation experimentally. Methods: Circular perforations of 2 mm diameter were performed at the nasal septum of 32 rats. Intranasal administration of hyperici oleum (HO), Triticum vulgare (TV), and thiocilline (T) was carried out twice a day for 7 days. After the rats were sacrificed at the end of the seventh day, their nasal septum specimens were sent for histological examination. The groups were compared in terms of epithelial regeneration, presence of fibroblasts and inflammatory cells, and capillary density parameters. Results: There was a statistically significant increase in the epithelialization mean scores in groups HO and TV compared to group P. When the groups were examined in terms of inflammation, a statistically significant increase was found in group HO. In terms of the fibroblast scores, a statistically significant increase was seen between group P and groups HO and T. The vascularization mean scores both in group HO and group TV were statistically significant when they were compared with groups C and P. Conclusion: The present study provides clues for preferring the use of TV and HO as a healer for the perforation area in the treatment of septum perforation. Based on the findings, widening the experiment and including additional parameters for understanding the healing mechanism will contribute to the clarification of the healing mechanism and thus to the development of the treatment options.