Use of Fe3 O4 @MPTMS-Dithizone Magnetic Nanoparticles as Solid Phase Sorbent for Sensitive Analysis of Sibutramine Molecules in Herbal Slimming Products

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dc.contributor.authorDemir, Özge
dc.contributor.authorUlusoy, Halil İbrahim
dc.contributor.authorPolat, Ümmügülsüm
dc.contributor.authorUlusoy, Songül
dc.date.accessioned2024-10-26T17:52:47Z
dc.date.available2024-10-26T17:52:47Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: A new enrichment and sensitive determination method, which includes HPLC-DAD analysis after Magnetic Solid Phase Extraction (MSPE), has been developed for trace analysis of Sibutramine molecules in herbal slimming products. Sibutramine is one of the most adulterated drug molecules in herbal products. Method: In the proposed method, Sibutramine molecules were pre-concentrated by using Fe3O4@MPTMS-Dithizone magnetic sorbent synthesized in our laboratory. Desorption of Sibutramine molecules from the sorbent phase was carried out by using acetonitrile: methanol (1:1) solvent in the presence of pH 8.0 buffer before chromatographic determinations. Results: Analytical parameters of the method, such as linear range, enrichment factor, and determination limit, were determined after optimizing experimental variables such as interaction time, desorption sol-vent, pH, etc. The sibutramine molecule was analyzed by isocratic elution of acetonitrile and KH2PO4 (pH 3.0, 0.05 M) (40:60) with a DAD detector at 223 nm wavelength. Limit of detection (LOD) value was calculated as 1.43 ng mL-1. Conclusion: Relative standard deviations (RSD) were below 3.20% for determinations of model solutions, including 100 ng mL-1 of Sibutramine. Finally, the developed method has been applied to herbal slimming tea samples with quantitative recovery experiments. © 2023 Bentham Science Publishers.
dc.description.sponsorshipCumhuriyet University Scientific Research Projects Commission, (ECZ-057)
dc.identifier.doi10.2174/1573411019666230703141135
dc.identifier.endpage481
dc.identifier.issn1573-4110
dc.identifier.issue6
dc.identifier.scopus2-s2.0-85168832008
dc.identifier.scopusqualityQ3
dc.identifier.startpage472
dc.identifier.urihttps://doi.org/10.2174/1573411019666230703141135
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26506
dc.identifier.volume19
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherBentham Science Publishers
dc.relation.ispartofCurrent Analytical Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectdrug analysis; herbal slimming products; HPLC; magnetic solid phase extraction; Sibutramine; sibutramine molecule
dc.titleUse of Fe3 O4 @MPTMS-Dithizone Magnetic Nanoparticles as Solid Phase Sorbent for Sensitive Analysis of Sibutramine Molecules in Herbal Slimming Products
dc.typeArticle

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