The effects of chlorhexidine gluconate and silver nitrate on rabbit lung: an experimental study

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dc.contributor.authorSahin, Ekber
dc.contributor.authorElagoz, Sahande
dc.contributor.authorCelik, Burcin
dc.contributor.authorNadir, Aydin
dc.contributor.authorKaradayi, Sule
dc.contributor.authorAkkas, Yucel
dc.contributor.authorKaptanoglu, Melih
dc.date.accessioned2024-10-26T18:07:15Z
dc.date.available2024-10-26T18:07:15Z
dc.date.issued2011
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: In this study, we investigated the effects of chlorhexidine gluconate and silver nitrate on the lungs and determine their utility in operations for pulmonary hydatid cysts. Methods: Thirty New Zealand Wistar albino rabbits weighing between 2750 and 3000 grams were used in the study and divided into three groups. In the first (control) group, normal saline (0.09% NaCl); in the second group, silver nitrate (0.5%); and in the third group, chlorhexidine gluconate (0.04%) was administered intrathraceally. Thirty days after the procedure, the tracheobronchial and parenchymal changes in the subjects were evaluated histopathologically. Tracheobronchial changes were evaluated with respect to tracheal pathology whereas peribronchial lymphocytic infiltration and parenchymal changes were evaluated with respect to interstitial lymphocytic infiltration, hemorrhage-edema, fibrosis and pneumonitis. Results: The rate of interstitial lymphocytic infiltration was higher in the chlorhexidine gluconate group than in the control group, and the rates of fibrosis and fibrin accumulation were higher in the silver nitrate group than in the control group. No statistically significant differences in other parameters were found between the groups. Conclusion: The results of the study indicate that chlorhexidine gluconate (0.04%) has minimal negative effects on the rabbit lung and tracheobronchial mucosa and is a more reliable agent than silver nitrate.
dc.description.sponsorshipCumhuriyet University Scientific Research Foundation [CUBAP T-321]
dc.description.sponsorshipThis work was supported by the Cumhuriyet University Scientific Research Foundation (CUBAP T-321).
dc.identifier.endpage71
dc.identifier.issn1301-5680
dc.identifier.issue1
dc.identifier.startpage67
dc.identifier.urihttps://hdl.handle.net/20.500.12418/29408
dc.identifier.volume19
dc.identifier.wosWOS:000286413200012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayincilik
dc.relation.ispartofTurk Gogus Kalp Damar Cerrahisi Dergisi-Turkish Journal of Thoracic and Cardiovascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChlorhexidine gluconate
dc.subjecthydatid cyst
dc.subjectpulmonary
dc.subjectsilver nitrate
dc.titleThe effects of chlorhexidine gluconate and silver nitrate on rabbit lung: an experimental study
dc.typeArticle

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