Investigation of the Protective Effects of Dexpanthenol and Boldine in Cisplatin-Induced Experimental Testis Injury Model in Rats

This study was carried out to determine the protective effects of dexpanthenol and boldin against \rpossible testicular damage caused by cisplatin. 48 Male Wistar rats (250-270 g) aged 4-5 months \rwere used in the study. 8 groups were formed with 6 animals in each group. Boldin (20 and 40\rmg/kg) and dexpentanol (250 and 500 mg/kg) were administered to rats along with cisplatin (7 \rmg/kg). At the end of the 14th day, spermatogenic and histopathological examinations and \rtesticular tissue malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase \r(GSH-Px) and catalase (CAT) levels were determined. A significant decrease in sperm quality and \rmotility, a significant increase in MDA, and a significant decrease in SOD, GSH-Px, and CAT levels \rwere observed in the cisplatin group. MDA levels were significantly lower in the other groups \rcompared to the cisplatin group. SOD, GSH-Px and CAT enzyme levels increased in the treatment \rgroups compared to the cisplatin group and approached the control group. Combined application of \rhigh doses of both substances with cisplatin reduced histopathological lesions. Significant \rincreases were found in the groups in which both doses of dexpanthenol and boldin were \rcombined with cisplatin compared to the cisplatin group. As a result, it was concluded that \rdexpanthenol and boldin treatments may have a protective effect against cisplatin-induced \rtesticular damage in rats.\r