Antimicrobial activities of bis-(N-alkylbenzimidazole)-cobalt(II) and zinc(II) complexes

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dc.contributor.authorŞahin, Neslihan
dc.contributor.authorÜstün, Elvan
dc.contributor.authorÖzdemir, İlknur
dc.contributor.authorGünal, Selami
dc.contributor.authorÖzdemir, Namık
dc.contributor.authorBülbül, Hakan
dc.contributor.authorGürbüz, Nevin
dc.date.accessioned2024-10-26T17:51:38Z
dc.date.available2024-10-26T17:51:38Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractEight benzimidazole precursors (L), namely 1-allyl-benzimidazole, 1-methallyl-benzimidazole, 1-isopropyl-benzimidazole, 1-(3-methyloxetan-3-yl)methyl-benzimidazole, 1-allyl-5,6-dimethyl-benzimidazole, 1-methallyl-5,6-dimethyl-benzimidazole, 1-isopropyl-5,6-dimethyl-benzimidazole and 1-(3-methyloxetan-3-yl)methyl-5,6-dimethyl-benzimidazole, were coordinated to cobalt(II) and zinc(II) cations to form complexes of the type [MCl2L2]. Single-crystal X-ray structures were determined for two cobalt(II) and for one zinc(II) complexes and confirmed their tetrahedral molecular geometry. The antibacterial and antifungal activities of these two series of cobalt(II) and zinc(II) complexes were studied against Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae), Gram-positive (Staphylococcus aureus, methicillin?resistant S. aureus and Enterococcus faecalis) bacteria and fungal strains (Candida albicans and Candida glabrata). Overall, cobalt(II) complexes were more effective than the zinc(II) complexes against all microorganisms. The most significant results were obtained with the two dichloro-bis(1-allyl-5,6-dimethylbenzimidazole)-cobalt(II) and dichloro-bis(1-methallyl-5,6-dimethylbenzimidazole)-cobalt(II) complexes against Candida albicans and Candida glabrata fungi with measured minimal inhibitory concentrations as low as 0.024 ?mol/mL, values close to those obtained with the commercially available drug Flucanozole (0.020 ?mol/mL). © 2023
dc.description.sponsorshipScientific Research Project Fund of Sivas Cumhuriyet University, (F-461)
dc.identifier.doi10.1016/j.inoche.2023.111396
dc.identifier.issn1387-7003
dc.identifier.scopus2-s2.0-85171326063
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1016/j.inoche.2023.111396
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26348
dc.identifier.volume157
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofInorganic Chemistry Communications
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntifungal activity; Antimicrobial activity; Benzimidazole ligand; Cobalt; X-ray crystallography; Zinc
dc.titleAntimicrobial activities of bis-(N-alkylbenzimidazole)-cobalt(II) and zinc(II) complexes
dc.typeArticle

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