Evaluation of toxic effects of rabeprazole sodium on the plant-based eukaryotic test models

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dc.contributor.authorIslam, Muhammad Torequl
dc.contributor.authorIriti, Marcello
dc.contributor.authorHarhar, Hicham
dc.contributor.authorElouafy, Youssef
dc.contributor.authorBhuia, Md. Shimul
dc.contributor.authorChamkhi, Imane
dc.contributor.authorGürer, Eda Sönmez
dc.date.accessioned2025-05-04T16:41:56Z
dc.date.available2025-05-04T16:41:56Z
dc.date.issued2024
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractBackground: Rabeprazole (RPZ), a widely used proton pump inhibitor, is known to have toxic effects on human beings. Objective: To evaluate the toxic effects of RPZ sodium (RPZ-Na) using plant-based eukaryotic test systems. Methods: The toxic effect of RPZ-Na (0.025-0.4 mM) was evaluated on Allium cepa, Allium sativum, and Cicer arietinum at different exposure times using CuSO4 as a reference standard. Results: RPZ-Na concentration-dependently reduced the root length of A. cepa and A. sativum, as well as the shoot and root lengths of C. arietinum. RPZ-Na at 0.1 to 0.4 µg/mL and at 48 h exposure time exerted toxic effects on the tested systems. Conclusions: RPZ-Na exerted a concentration-and time-dependent toxic effect on A. cepa, A. sativum, and C. arietinum. Therefore, it is important to take adequate precautions during its long-term use. © 2024, Universidad de Antioquia. All rights reserved.
dc.identifier.doi10.17533/udea.vitae.v31n2a352429
dc.identifier.issn0121-4004
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85205969838
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.17533/udea.vitae.v31n2a352429
dc.identifier.urihttps://hdl.handle.net/20.500.12418/34991
dc.identifier.volume31
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniversidad de Antioquia
dc.relation.ispartofVitae
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250504
dc.subjectAllium cepa
dc.subjectAllium sativum
dc.subjectCicer arietinum
dc.subjectRabeprazole sodium
dc.subjectToxicity monitoring tools
dc.titleEvaluation of toxic effects of rabeprazole sodium on the plant-based eukaryotic test models
dc.typeArticle

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