The effect of platelet-rich plasma on intra-abdominal adhesions in rabbit uterine horn model

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dc.contributor.authorKurt, Begum
dc.contributor.authorYildiz, Caglar
dc.contributor.authorKoc, Tulay
dc.contributor.authorKurt-Ozkaya, Nese
dc.contributor.authorCelikgun, Serkan
dc.date.accessioned2024-10-26T17:52:49Z
dc.date.available2024-10-26T17:52:49Z
dc.date.issued2023
dc.departmentSivas Cumhuriyet Üniversitesi
dc.description.abstractObjective: This study was carried out to investigate the effect of autologous platelet-rich plasma (PRP) on intra-abdominal adhesion at the cesarean section incision line in the uterus. Material and methods: As experimental animals 16 white New Zealand rabbits, 5-months-old, unmated, were used. Animals were divided into two groups the control group and PRP application group. In each group, a transverse incision was made to the uterus to mimic the cesarean section and sutured. Relaparotomy was performed 21 days after the first operation. Results: When the groups were evaluated in terms of inflammation, there was a significant difference between the two groups. When the groups were evaluated in terms of Mason’s Trichrome staining and fibrosis, There was a significant difference between groups. When the groups were evaluated in terms of vascular endothelial growth factor-1, there was also a significant difference between the groups. In an experimental rabbit uterine horn adhesion model, PRP is effective in preventing post-operative adhesion formation. Conclusions: This result may guide clinical studies using autologous PRP to prevent post-operative adhesion formation after gynecological operations. © 2023 Academia Mexicana de Cirugía. Published by Permanyer. This is an open access article under the terms of the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.description.sponsorshipSivas Cumhuriyet Üniversitesi, (T-2022-942)
dc.identifier.doi10.24875/CIRU.23000070
dc.identifier.endpage779
dc.identifier.issn0009-7411
dc.identifier.issue6
dc.identifier.pmid38096877
dc.identifier.scopus2-s2.0-85179774527
dc.identifier.scopusqualityQ4
dc.identifier.startpage773
dc.identifier.urihttps://doi.org/10.24875/CIRU.23000070
dc.identifier.urihttps://hdl.handle.net/20.500.12418/26539
dc.identifier.volume91
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPermanyer Publications
dc.relation.ispartofCirugia y Cirujanos (English Edition)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGynecological surgery; Platelet-rich plasma; Post-operative complications- Repeat cesarean sections; Surgical adhesions
dc.titleThe effect of platelet-rich plasma on intra-abdominal adhesions in rabbit uterine horn model
dc.title.alternativeEl efecto del plasma rico en plaquetas en las adherencias intraabdominales en modelo de cuerno uterino de conejo
dc.typeArticle

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