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dc.contributor.authorTopcu, Omer
dc.contributor.authorKurt, Atilla
dc.contributor.authorNadir, Isilay
dc.contributor.authorArici, Sema
dc.contributor.authorKoyuncu, Ayhan
dc.contributor.authorAydin, Cengiz
dc.date.accessioned2019-07-27T12:10:23Z
dc.date.accessioned2019-07-28T10:14:01Z
dc.date.available2019-07-27T12:10:23Z
dc.date.available2019-07-28T10:14:01Z
dc.date.issued2009
dc.identifier.issn1007-9327
dc.identifier.urihttps://dx.doi.org/10.3748/wjg.15.4788
dc.identifier.urihttps://hdl.handle.net/20.500.12418/10035
dc.descriptionWOS: 000270841600009en_US
dc.descriptionPubMed ID: 19824112en_US
dc.description.abstractAIM: To determine the effects of high osmolarity contrast media (HOCM) and iso-osmolar contrast. media (CM) application, with or without pressure, on hepato-pancreato-biliary (HPB) system. METHODS: Sixty rats were divided into six equal groups as follows: Group 1: (0.9% NaCl, control), Group 2: (diatrizoate meglumine Na, ionic HOCM, Urographin (R)), Group 3: (iodixanol, iso-osmolar nonionic CM, Visipaque (R)); each of which was applied without pressure, whereas the animals of the remaining three groups (1p, 2p, 3p) were subjected to the same CM with pressure. We performed a duodenal puncture and introduced a catheter into the ampulla. After the catheterization, 0.2 mL CM or 0.9% NaCl was injected with or without pressure. Blood samples were taken for biochemical evaluations. The histopathological examinations of liver, common bile duct, and pancreas were performed. RESULTS: There were no significant differences between the six groups for blood amylase, alanine aminotransferases, aspartate aminotransferases, bilirubin levels (P > 0.05). Alkaline phosphatase and gamma glutamyl transaminase levels were higher (P < 0.05) in the Urographin (R) groups (2, 2p) than the Visipaque (R) groups (3, 3p), or control groups (1, 1p). Hepatocyte necrosis, portal area inflammation, and Kupffer's cell hyperplasia were higher (P < 0.05) in the study groups than the control group. However, there were no significant differences (P > 0.05) between HOCM (2, 2p) and iso-osmolar CM (3, 3p) groups. Bile duct proliferation and regeneration in the Urographin (R) groups (2, 2p) were significantly higher (P < 0.05) than the Visipaque (R) groups (3, 3p) or the control groups (1, 1p). Although CM caused minor damage to the pancreas, there were no statistically significant differences (P > 0.05) between the groups. Application of the CM with pressure did not cause additional damage to the HPB system. CONCLUSION: Iso-osmolar, non-ionic CM could be more reliable than the ionic HOCM, whereas the application of pressure during the CM application had no effect on the HPB system. (C) 2009 The WJG Press and Baishideng. All rights reserved.en_US
dc.language.isoengen_US
dc.publisherW J G PRESSen_US
dc.relation.isversionof10.3748/wjg.15.4788en_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectContrast mediaen_US
dc.subjectLiveren_US
dc.subjectPancreasen_US
dc.subjectBiliary tracten_US
dc.subjectPressureen_US
dc.titleEffects of contrast media on the hepato-pancreato-biliary systemen_US
dc.typearticleen_US
dc.relation.journalWORLD JOURNAL OF GASTROENTEROLOGYen_US
dc.contributor.department[Topcu, Omer -- Kurt, Atilla -- Koyuncu, Ayhan -- Aydin, Cengiz] Cumhuriyet Univ, Dept Gen Surg, Fac Med, TR-58140 Sivas, Turkey -- [Nadir, Isilay] Numune Hosp, Dept Gastroenterol, TR-58140 Sivas, Turkey -- [Arici, Sema] Cumhuriyet Univ, Dept Pathol, Fac Med, TR-58140 Sivas, Turkeyen_US
dc.identifier.volume15en_US
dc.identifier.issue38en_US
dc.identifier.endpage4793en_US
dc.identifier.startpage4788en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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