Adult height in Turkish patients with Turner syndrome without growth hormone treatment
Date
2008Author
Bereket, AbdullahTuran, Serap
Elcioglu, Nursel
Hacihanefioglu, Seniha
Memioglu, Nihal
Bas, Firdevs
Bundak, Rueveyde
Darendeliler, Feyza
Guenoez, Huelya
Saka, Nurcin
Ercan, Oya
Arslanoglu, Ilknur
Isgueven, Pinar
Yildiz, Metin
Can, Sule
Oezerkan, Ebru
Coker, Mahmut
Darcan, Suekran
Oezkan, Behzat
Orbak, Zerrin
Oeztas, Sitki
Palanduez, Suekrue
Sezgin, Ilhan
Atabek, Emre
Erkul, Ibrahim
Erdogan, Guerbuez
Metadata
Show full item recordAbstract
Spontaneous adult height (AH) in Turner syndrome (TS) varies among populations. Population-specific AH data is essential to assess the efficacy of growth-promoting therapies in TS. A multicenter study was performed to establish AH of non-growth hormone (GH)-treated Turkish patients with TS. One hundred ten patients with TS (diagnosed by karyotype) who reached AH (no growth in the previous year, or bone age > 15 years) without receiving GH treatment were included in the study. The average AH was found to be 141.6 +/- 7.0 cm at the age of 22.9 +/- 6.2 years, which is 18.4 cm below the population average and 16.4 cm below the patients' mid-parental heights. Bone age at start of estrogen replacement was 12.3 +/- 1.3 year. Karyotype distribution of the patients was 45X (43%), 4SX/46XX (16%), 4SX/46xi (12%), 45XiXq (10%) and others (19%). When the patients were evaluated according to their karyotype as 45X and non-45X, no significant difference in AH was observed (142.4 +/- 6.9 cm vs 140.9 +/- 7.1 cm, respectively). Adult height of non-GH-treated Turkish TS patients obtained in this study was comparable to that of other Mediterranean populations, but shorter than that of Northern European patients. Karyotype does not seem to affect AH in TS.
Source
TURKISH JOURNAL OF PEDIATRICSVolume
50Issue
5Collections
- Makale Koleksiyonu [5200]
- Makale Koleksiyonu [5745]
- Öksüz Yayınlar Koleksiyonu - WoS [6162]