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Isatin/thiosemicarbohydrazone hybrids: Facile synthesis, and their evaluation as anti-proliferatıve agents and metabolıc enzyme inhibitors
(AJOL, 2023/7/3)
We are reporting a novel series of thiosemicarbazone derivatives derived from isatin (1-6), structural determination, and investigation of the inhibitory properties against proliferative, carbonic anhydrase, and cholinesterase ...
Anticancer activity, hTERT expression and telomere length analysis in SH-SY5Y neuroblastoma cell lines applied to docetaxel
(Elsevier, 05.02.2023)
Neuroblastoma is the most common extracranial solid tumor of infancy in a broad range of clinical courses, ranging from spontaneous regression to fatal progression. Telomere maintenance plays an impor- tant role in genome ...
Fabrication and Characterization of High Performance PVDF-based flexible piezoelectric nanogenerators using PMN-xPT (x: 30, 32.5, and 35) particles
(Elsevier, 01/06/2023)
Flexible piezoelectric nanogenerators based on polyvinylidene difluoride (PVDF) and lead magnesium niobate-lead titanate Pb(Mg1/3Nb2/3)O3–PbTiO3(PMN-xPT compositions for x between 30 and 35) particles with various filler ...
Application of Spectral Analysis and Image Processing Methods to Discriminate Hydrothermal Alteration Minerals Around the Tutakdağı (Şebinkarahisar-Giresun) Lead–Zinc Deposits, Northeastern Turkey
(Springer, Ağustos 20)
The Tutakdağı (Şebinkarahisar-Giresun) area is located in the southern part of the Eastern Pontides, northeastern Turkey. It contains numerous types of mineralization, examples include massive sulfide, porphyry, skarn, and ...
Effect of azomethine group containing compounds on gene profiles in Wnt and MAPK signal patterns in lung cancer cell line: In silico and in vitro analyses
(Elsevier, 2023/3/5)
The main aims of anticancer drug development studies is to reduce the toxicity of the developed com pound and maximize the effectiveness, as well as the discovery of artificial and natural compounds. In
recent years, ...
In vitro cytotoxic effects, in silico studies, some metabolic enzymes inhibition, and vibrational spectral analysis of novel β-amino alcohol compounds
(Elsevier, 05.02.2023)
In this study, an efficient single-step method for the preparation of β-amino alcohols ( 1 –3 ) in aqueous media was applied. The aim was to investigate the cytotoxic activity of Compounds 1, 2 and 3 in neu- roblastoma ...
Investigation of Early Growth Response Protein (EGR) Levels in Patients with Fibromyalgia Syndrome: A Cross-Sectional Study
(Bentham Science Publishers, 01.12.2023)
Background:
Fibromyalgia is a soft tissue rheumatism characterized by chronic and
widespread musculoskeletal pain at specific points in the body.
Objectives:
In this study, we aimed to investigate the relationship ...
Experimental and theoretical insights about the effect of some newly designed azomethine group-contained macroheterocycles on oxidative stress and DNA repair gene profiles in neuroblastoma cell lines
(Elsevier, 05.09.2023)
We report herein the synthesis of new azomethine group containing forty-, sixty-eight- and seventy- two-membered macroheterocyclic compounds and the investigation of their activity against the neurob- lastoma cell line. ...
Effect of azomethine group containing compounds on gene profiles in Wnt and MAPK signal patterns in lung cancer cell line: In silico and in vitro analyses
(Elsevier, 05.03.2023)
The main aims of anticancer drug development studies is to reduce the toxicity of the developed compound and maximize the effectiveness, as well as the discovery of artificial and natural compounds. In recent years, ...
Piperazin incorporated Schiff Base derivatives: Assessment of in vitro biological activities, metabolic enzyme inhibition properties, and molecular docking calculations
(2023)
The cytotoxic activities of the compounds were determined by the 3‐(4,
5‐dimethylthiazolyl‐2)‐2,5‐diphenyltetrazolium bromide (MTT) method in human
breast cancer (MCF‐7), human cervical cancer (HeLa), and mouse fibroblast ...