Browsing Sivas Cumhuriyet Üniversitesi Eczacılık Fakültesi by Language "eng"
Now showing items 41-60 of 82
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Investigating the effects of the Rho-kinase enzyme inhibitors AS1892802 and fasudil hydrochloride on the contractions of isolated pregnant rat myometrium
(ELSEVIER SCIENCE BV, 2016)Objectives: Rho-kinases (ROCKs), are one of the dynamic structures of the actin cytoskeleton and they mediate different biological processes, including regulation of calcium sensitivity of smooth muscle contraction. The ... -
Investigation of Interaction of Bismarck Brown Y-Palladium Complex with AS1411 G-quadruplex Aptamer
(29.12.2022)Increased metabolic activity and metastasis are the main and most known characteristics of cancer cells. Increased activity of the cells results in an increase in the transcription, translation, and replication rate of ... -
INVESTIGATION OF SALVIA CADMICA’S ANTIOXIDANT PROPERTIES AND CYTOTOXIC PROPERTIES IN BREAST CANCER CELL LINE AND ITS APOPTOTIC INDUCTION
(30.05.2023)Salvia cadmica is an endemic species known to have antioxidant, antimicrobial and aromatic properties and the existence of Salvia species is known to date back to 753 BC. This species, whose medicinal properties were ... -
Investigation of the Antimicrobial Agent Potential of 1,5-diketon Derivatives
(2021)In this study 1,5-diketones were synthesized by adding of cyclohexzanone to five differtent calcone derivatives (1a-e) via di-1,4-Michael addition reaction. As a result the compounds with the best activity were 3a, 3b and ... -
INVESTIGATION OF THE ANTIPROLIFERATIVE EFFECT OF SALVIA CADMICA ON COLON CANCER
(07.05.2023)Salvia cadmica is an endemic species known to have antioxidant, antimicrobial and aromatic properties and the existence of Salvia species is known to date back to 753 BC. This species, whose medicinal properties were ... -
Investigation of the Relationship between the Chemical Structures and the Cytotoxicity of Some Maleic Anhydride-Containing Copolymers as Polymeric Drug Carriers
(23.11.2023)Polymer-based substances have been an important biomaterial in the advancement of drug delivery systems as they enabled the controlled release of therapeutic agents in fixed doses with high bioavailability, lower toxicity, ... -
Ionic Liquids in Analytical Chemistry: Applications and Recent Trends
(03.07.2021)Background: Ionic liquids (ILs) are a unique class of compounds consisting exclusively of cations and anions that possess distinctive properties such as low volatility, high thermal stability, miscibility with water and ... -
Isatin/thiosemicarbohydrazone hybrids: Facile synthesis, and their evaluation as anti-proliferatıve agents and metabolıc enzyme inhibitors
(AJOL, 2023/7/3)We are reporting a novel series of thiosemicarbazone derivatives derived from isatin (1-6), structural determination, and investigation of the inhibitory properties against proliferative, carbonic anhydrase, and cholinesterase ... -
Mechanism of anticancer effect of ETP‑45658, a PI3K/AKT/mTOR pathway inhibitor on HT‑29 Cells
(27. 10. 20)The PI3K pathway plays a crucial role in tumor cell proliferation across various cancers, including colon cancer, making it a promising treatment target. This study aims to investigate the antiproliferative activity of ... -
Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma
(16. 08. 20)Gambogic acid has demonstrated inhibitory effects on the growth of various cancer cell types, such as breast cancer, pancreatic cancer, prostate cancer, lung cancer, and osteosarcoma. This study aims to investigate the ... -
Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
(WİLLEY ONLİNE LİBRARY, 2021)A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahydrocyclopenta[ a]inden-8(1H)-one derivatives were synthesized from KOtBu mediated Michael/Michael addition reaction of 2- benzylidene-1-indanones with ... -
Molecular hybrids integrated with imidazole and hydrazone structural motifs: Design, synthesis, biological evaluation, and molecular docking studies
(Elsevier, 2023/12/1)In the present work, a series of compounds containing imidazole and hydrazone structural frameworks were synthesized and characterized using various spectral techniques, including 1H NMR, 13C NMR, FTIR, and HRMS. Synthesized ... -
New benzimidazole‐oxadiazole derivatives: Synthesis, α‐glucosidase, α‐amylase activity, and molecular modeling studies as potential antidiabetic agents
(23.01.2023)Benzimidazole‐1,3,4‐oxadiazole derivatives (5a–z) were synthesized and characterized with different spectroscopic techniques such as 1 HNMR, 13 CNMR,andHRMS.The synthesized analogs were examined against α‐glucosidase ... -
New imidazole derivatives as aromatase inhibitor: Design, synthesis, biological activity, molecular docking, and computational ADME-Tox studies
(06.01.2023)In this study, a series of imidazole derivatives was designed, synthesized, and evaluated for in vitro bi- ological activity on the human breast cancer cell line MCF7 by MTT assay. To determine the selectivity of the ... -
Novel Applications of Microextraction Techniques Focused on Biological and Forensic Analyses
(MDPI, 15.02.2022)In recent years, major attention has been focused on microextraction procedures that allow high recovery of target analytes, regardless of the complexity of the sample matrices. The most used techniques included liquid-liquid ... -
Novel ultra-stretchable and self-healing crosslinked poly (ethylene oxide)-cationic guar gum hydrogel
(Ekim 2023)AbstractHydrogels are three-dimensional structures with specific features that render them useful for biomedical applications, such as tissue engineering scaffolds, drug delivery systems, and wound dressings. In recent ... -
One-pot modification of oleate-capped UCNPs with AS1411 G-quadruplex DNA in a fully aqueous medium
(5 June 202)In the present work, modification of oleate-capped upconverting nanoparticles (OA@UCNPs) with AS1411 G-quadruplex DNA by a one-pot aqueous strategy was presented. The G-quadruplex structure of AS1411 and structural alterations ... -
Pharmaco-Metabolomics: Drug Effects on Metabolites
(Nova Science Publishers, 2023)The development and advancements in technology, artificial intelligence, and fields of bioinformatics, enabled the use of enormous data coming from genes, transcripts, and proteins processed by the omics in medicine as ... -
Pharmacokinetic Profiles of Metamizole Metabolites after Intramuscular and Intravenous Administration in Healthy Arabian Horses
(2021)Metamizole sodium (MT) is an analgesic and antipyretic drug molecule used in humans, horses, cattle, swine, and dogs. Metamizole rapidly hydrolyzes and turns into methyl amino antipyrine (MAA), an active primary metabolite ... -
Phenolic content, antioxidant and antimicrobial activities evaluation and relationship of commercial spices in the lebanese market
(Kasım 2023)AbstractLebanese cuisine is renowned for its distinctive flavours and vibrant aromas. In Lebanese cuisine, spices are not just used for their flavour; they are also valued for their medicinal properties. This study consists ...