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Synthesis, molecular docking, and biological activities of new cyanopyridine derivatives containing phenylurea
(Wiley-VCH GmbH, Weinheim, 2021/4)
A new class of cyanopyridine derivatives (10a–e and 11a–e) containing the
phenylurea unit was synthesized and tested against some metabolic enzymes
including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ...
Use of newly synthetized magnetic Fe3O4 nanoparticles modified with hexadecyl trimethyl ammonium bromide for the sensitive analysis of antidepressant drugs, duloxetine and vilazodone in wastewater and urine samples
(RSC, 17th June )
A new enrichment and determination method involving HPLC-DAD analysis following magnetic solidphase
extraction (MSPE) was developed to detect trace amounts of two antidepressant drugs, namely,
duloxetine (DUL) and ...
Mechanism of anticancer effect of gambogic acid on gastric signet ring cell carcinoma
(16. 08. 20)
Gambogic acid has demonstrated inhibitory effects on the growth of various cancer cell types, such as breast cancer, pancreatic
cancer, prostate cancer, lung cancer, and osteosarcoma. This study aims to investigate the ...
Mechanism of anticancer effect of ETP‑45658, a PI3K/AKT/mTOR pathway inhibitor on HT‑29 Cells
(27. 10. 20)
The PI3K pathway plays a crucial role in tumor cell proliferation across various cancers, including colon cancer, making it a promising treatment target. This study aims to investigate the antiproliferative activity of ...
The Role of Nitric Oxide Pathway in the Anti-Epileptogenic Effect of Valproic Acid in the Pentylenetetrazole-Kindling Model in Rats
(02. 06. 20)
Though valproic acid (VPA) is used to treat seizures, more investigations have been needed to understand the effect of VPA on the nitric oxide pathway in epilepsy. Our investigation aimed to study the effect of VPA on ...
Anticancer activity of lycopene in HT‑29 colon cancer cell line
(24. 03. 20)
An inverse association between serum lycopene levels and the risk of cancers has been pointed out by many prospective and retrospective epidemiological studies which prompted more studies to be performed on animal models ...
Application of magnetic solid‑phase extraction for sensitive determination of anticancer drugs in urine by means of diamino benzidine tetrachlorohydrate modified magnetic nanoparticles
(Şubat, 202)
Background The analysis of drug active molecules and residues in the treatment of cancer is important for the sustainability of
human life and therapeutic effects. For this purpose, a new magnetic sorbent was developed ...
Azinphos-methyl and chlorfenvinphos pesticides determination using fabric phase sorptive extraction followed by high performance liquid chromatography-photodiode array detector
(Elsevier, 25 April 2)
A reliable and efficient fabric phase sorptive extraction method was developed for the rapid analysis of azinphosmethyl
and chlorfenvinphos pesticide residues in wastewater and fruit juice samples using high-performance
liquid ...
Composition characterization and biological activity study of Achillea vermicularis extract and extract‐loaded nanoparticles
(JUMB, 2023/1/9)
Antiproliferative activity of Achillea vermicularis extracts was calculated on glial (C6) and keratinocyte (HaCaT) cell lines using XTT assay. It was observed that all extracts of A. vermicularis at the determined concentration ...
Piperazin incorporated Schiff Base derivatives: Assessment of in vitro biological activities, metabolic enzyme inhibition properties, and molecular docking calculations
(WİLEY, 2023/11)
The cytotoxic activities of the compounds were determined by the 3‐(4,
5‐dimethylthiazolyl‐2)‐2,5‐diphenyltetrazolium bromide (MTT) method in human
breast cancer (MCF‐7), human cervical cancer (HeLa), and mouse fibroblast ...