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Relationship of tobacco smoking with GSTM1 gene polymorphism in laringeal cancer

Date

2003

Author

Bardakci, F
Canbay, E
Degerli, N
Coban, L
Canbay, E

Metadata

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Abstract

This paper aimed to analyze the association of polymorphism of GSTM1 0/0 genotype with laryngeal cancer along a hospital based case-control study. Polymorphisms of GSTM 1 0/0 of samples from 36 patients with laryngeal cancer and 3 5 healthy controls were detected by PCR method. The reaction used as GSTM I primers, using the sequence sense: 5'-CTGCCCTACTTGGATTGATGGG-3' and antisense: 5'-TGGATTGTAGCAGATCATGC-3'. N Acetyl transferase I (NAT1) gene using the primers sense: 5'-TAAAAGTAAAATGATTTGCTTTCG-3' and antisense: 5'-GCTTTCTAGCATAAATCACCAA-3' was used as internal positive control. Two sided 2 and multivariation analysis were used to analyse the results. The proportions of GSTM I deleted genotype in cases and controls were 47.2% and 54.3%, respectively. There was significant increment of GSTM 0/0 genotype frequency in moderate smokers group of patients compared to control (P=0.033, OR=4.78, 95% Cl=1.30-7.13). We conclude that GSTM1 deleted genotype may be a genetic susceptibility marker for laryngeal cancer whose exposed to low doses carcinogens. The absence of this enzyme seems to have a role in the development of laryngeal cancer, in which the mechanism still needs further investigation.

Source

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Volume

7

Issue

3

URI

https://dx.doi.org/10.1111/j.1582-4934.2003.tb00231.x
https://hdl.handle.net/20.500.12418/11371

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  • Makale Koleksiyonu [5200]
  • Makale Koleksiyonu [5745]
  • Öksüz Yayınlar Koleksiyonu - WoS [6175]



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