dc.contributor.author | Bardakci, F | |
dc.contributor.author | Canbay, E | |
dc.contributor.author | Degerli, N | |
dc.contributor.author | Coban, L | |
dc.contributor.author | Canbay, E | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:23:27Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:23:27Z | |
dc.date.issued | 2003 | |
dc.identifier.issn | 1582-4934 | |
dc.identifier.uri | https://dx.doi.org/10.1111/j.1582-4934.2003.tb00231.x | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11371 | |
dc.description | WOS: 000224538000012 | en_US |
dc.description | PubMed ID: 14594555 | en_US |
dc.description.abstract | This paper aimed to analyze the association of polymorphism of GSTM1 0/0 genotype with laryngeal cancer along a hospital based case-control study. Polymorphisms of GSTM 1 0/0 of samples from 36 patients with laryngeal cancer and 3 5 healthy controls were detected by PCR method. The reaction used as GSTM I primers, using the sequence sense: 5'-CTGCCCTACTTGGATTGATGGG-3' and antisense: 5'-TGGATTGTAGCAGATCATGC-3'. N Acetyl transferase I (NAT1) gene using the primers sense: 5'-TAAAAGTAAAATGATTTGCTTTCG-3' and antisense: 5'-GCTTTCTAGCATAAATCACCAA-3' was used as internal positive control. Two sided 2 and multivariation analysis were used to analyse the results. The proportions of GSTM I deleted genotype in cases and controls were 47.2% and 54.3%, respectively. There was significant increment of GSTM 0/0 genotype frequency in moderate smokers group of patients compared to control (P=0.033, OR=4.78, 95% Cl=1.30-7.13). We conclude that GSTM1 deleted genotype may be a genetic susceptibility marker for laryngeal cancer whose exposed to low doses carcinogens. The absence of this enzyme seems to have a role in the development of laryngeal cancer, in which the mechanism still needs further investigation. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | WILEY | en_US |
dc.relation.isversionof | 10.1111/j.1582-4934.2003.tb00231.x | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | carcinoma | en_US |
dc.subject | squamous cell | en_US |
dc.subject | laryngeal neoplasms | en_US |
dc.subject | gene deletion | en_US |
dc.subject | GSTM1 | en_US |
dc.subject | alleles | en_US |
dc.subject | gene frequency | en_US |
dc.title | Relationship of tobacco smoking with GSTM1 gene polymorphism in laringeal cancer | en_US |
dc.type | article | en_US |
dc.relation.journal | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | en_US |
dc.contributor.department | Cumhuriyet Univ Hosp, Dept Gen Surg, TR-58140 Sivas, Turkey -- Cumhuriyet Univ Hosp, Dept Otorhinolaryngol, TR-58140 Sivas, Turkey -- Cumhuriyet Univ Hosp, Fac Sci, Dept Biol, TR-58140 Sivas, Turkey | en_US |
dc.identifier.volume | 7 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.endpage | 312 | en_US |
dc.identifier.startpage | 307 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |