dc.contributor.author | Leylek, OA | |
dc.contributor.author | Toyaksi, M | |
dc.contributor.author | Erselcan, T | |
dc.contributor.author | Dokmetas, S | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:26:01Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:26:01Z | |
dc.date.issued | 1999 | |
dc.identifier.issn | 0378-7346 | |
dc.identifier.uri | https://dx.doi.org/10.1159/000010111 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11776 | |
dc.description | WOS: 000080776400003 | en_US |
dc.description | PubMed ID: 10352382 | en_US |
dc.description.abstract | Objective: This study was set up to investigate the relationship between immune process and high levels of human chorionic gonadotropin-beta (beta hCG) in hyperemesis patients with or without hyperthyroxinemia. Methods: beta hCG, immune parameters and thyroid related hormones were assayed in hyperemesis patients and in controls. Results: Mean serum beta hCG, fT4 and TSH levels were significantly higher in hyperemesis patients than in controls (p < 0.01, p < 0.01, p < 0.05, respectively). Further, immune parameters regarding IgG, IgM, C3 C4 and lymphocyte count were significantly higher in patients than in controls (p < 0.05, p < 0.01, p < 0.01, p < 0.05, p < 0.01, respectively). In hyperemesis patients with hyperthyroxinemia, mean serum beta hCG, IgG and IgM were significantly higher than in hyperemesis women without hyperthyroxinemia (p < 0.001, p < 0.05, p < 0.05, respectively). beta hCG was positively correlated with fT4 (r = 0.45, p < 0.05), with lymphocyte count (r = 0.47, p < 0.01), with IgM (r = 0.38, p < 0.05) and with C3 (r = 0.40, P < 0.05) in hyperemesis patients. A negative correlation between beta hCG and ISH (r = -0.43, p < 0.05) was noted in the hyperemesis group. Free T-4 showed a positive association to IgM (r = 0.49, p < 0.01), to IgG (r = 0.40, p < 0.05), to lymphocyte count (r = 0.45, p < 0.05). Conclusion: Immunologic activity in pregnancy may have an effect or role on the stimulatory mechanism of beta hCG in hyperemesis patients with or without hyperthyroxinemia. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | KARGER | en_US |
dc.relation.isversionof | 10.1159/000010111 | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | hyperemesis gravidarum | en_US |
dc.subject | immunology | en_US |
dc.subject | thyroid | en_US |
dc.title | Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia | en_US |
dc.type | article | en_US |
dc.relation.journal | GYNECOLOGIC AND OBSTETRIC INVESTIGATION | en_US |
dc.contributor.department | Cumhuriyet Univ, Sch Med, Dept Gynecol & Obstet, Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Nucl Med, Sivas, Turkey -- Cumhuriyet Univ, Sch Med, Dept Internal Med, Div Endocrinol, Sivas, Turkey | en_US |
dc.identifier.volume | 47 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.endpage | 234 | en_US |
dc.identifier.startpage | 229 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |