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ALTERED ENDOTHELIUM-MEDIATED RELAXATION BY SYMPATHECTOMY IN ISOLATED RABBIT CAROTID-ARTERY RINGS

Date

1995

Author

KAYA, T
UTKAN, T
SARIOGLU, Y
GOKSEL, M

Metadata

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Abstract

The influence of cervical and periarterial sympathectomy on endothelium-dependent and endothelium-independent relaxations of the mature rabbit carotid artery was studied in vitro. The responses to adenosine, vasoactive intestinal polypeptide and substance P in sympathectomized and control rabbit carotid artery rings were recorded and analyzed. The effects of endothelium removal were also investigated. The maximal relaxation achieved by substance P, which produces endothelium-dependent relaxation, was significantly inhibited in 3 weeks in postsympathectomy arterial preparations as compared to controls. Adenosine and vasoactive intestinal polypeptide, which produce endothelium-independent relaxation, elicited similar relaxation in all tissues. These results demonstrated that the response to substance P was impaired by cervical and periarterial sympathectomy. The decreased maximum response to substance P may be the result of a decreased NK-1 receptor subtype density or excitation/response coupling, or it may be due to an impaired production and/or liberation of endothelium-derived relaxing factor (EDRF).

Source

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY

Volume

17

Issue

6

URI

https://hdl.handle.net/20.500.12418/11915

Collections

  • Makale Koleksiyonu [5200]
  • Öksüz Yayınlar Koleksiyonu - WoS [6162]



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