dc.contributor.author | KAYA, T | |
dc.contributor.author | UTKAN, T | |
dc.contributor.author | SARIOGLU, Y | |
dc.contributor.author | GOKSEL, M | |
dc.date.accessioned | 2019-07-27T12:10:23Z | |
dc.date.accessioned | 2019-07-28T10:38:49Z | |
dc.date.available | 2019-07-27T12:10:23Z | |
dc.date.available | 2019-07-28T10:38:49Z | |
dc.date.issued | 1995 | |
dc.identifier.issn | 0379-0355 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/11915 | |
dc.description | WOS: A1995RW39000003 | en_US |
dc.description | PubMed ID: 8642897 | en_US |
dc.description.abstract | The influence of cervical and periarterial sympathectomy on endothelium-dependent and endothelium-independent relaxations of the mature rabbit carotid artery was studied in vitro. The responses to adenosine, vasoactive intestinal polypeptide and substance P in sympathectomized and control rabbit carotid artery rings were recorded and analyzed. The effects of endothelium removal were also investigated. The maximal relaxation achieved by substance P, which produces endothelium-dependent relaxation, was significantly inhibited in 3 weeks in postsympathectomy arterial preparations as compared to controls. Adenosine and vasoactive intestinal polypeptide, which produce endothelium-independent relaxation, elicited similar relaxation in all tissues. These results demonstrated that the response to substance P was impaired by cervical and periarterial sympathectomy. The decreased maximum response to substance P may be the result of a decreased NK-1 receptor subtype density or excitation/response coupling, or it may be due to an impaired production and/or liberation of endothelium-derived relaxing factor (EDRF). | en_US |
dc.language.iso | eng | en_US |
dc.publisher | J R PROUS SA | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | SYMPATHECTOMY | en_US |
dc.subject | CAROTID ARTERY | en_US |
dc.subject | SUBSTANCE P | en_US |
dc.subject | VIP | en_US |
dc.subject | ADENOSINE | en_US |
dc.title | ALTERED ENDOTHELIUM-MEDIATED RELAXATION BY SYMPATHECTOMY IN ISOLATED RABBIT CAROTID-ARTERY RINGS | en_US |
dc.type | article | en_US |
dc.relation.journal | METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | en_US |
dc.contributor.department | CUMHURIYET UNIV,FAC MED,DEPT PHARMACOL,SIVAS 58140,TURKEY -- CUMHURIYET UNIV,FAC MED,DEPT NEUROSURG,SIVAS 58140,TURKEY | en_US |
dc.contributor.authorID | SARIOGLU, YUSUF -- 0000-0002-9227-365X | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.endpage | 375 | en_US |
dc.identifier.startpage | 369 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |