Browsing Sivas Cumhuriyet Üniversitesi Tıp Fakültesi by Author "0000-0001-8738-0760"
Now showing items 1-13 of 13
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A novel therapeutic approach to NASH: Both polyethylene glycol 3350 and lactulose reduce hepatic inflammation in C57BL/6J mice.
Pinar Gokcen; Oguzhan Ozturk; Gupse Adali; Ilkay Tosun; Halef Okan Dogan; Haki Kara; Yucel Yalman; Hamdi Doganay; Kamil Ozdil (2021)Background. The gut-liver axis is one of the most emphasized topics in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Intestinal microbiota dysbiosis has been shown to be a predictor of disease severity and ... -
AKILCI LABORATUVAR İSTEMİ YAPABİLME
Dogan, Halef Okan; Çalcı, Esin (2022)Clinicians in healthcare institutions often use laboratory data when making decisions about patients.When laboratory requests are made correctly, it contributes significantly to the diagnosis and treatment of the patient, ... -
Assessment of semaphorin 3A and semaphorin 7A levels in primary Sjogren's syndrome
Urhan, Emre; Urhan, Ayse Camci; Dogan, Halef Okan; Sahin, Ali (Springer, 2022/8/28)Sjogren's syndrome (SS) is a chronic autoimmune connective tissue disease. Varying rates of system involvements may be seen in the course of the disease. Semaphorins has multifunctions in several physiological and pathological ... -
Assessment of semaphorin 3A and semaphorin 7A levels in primary Sjogren's syndrome
Halef Okan Dogan (Springer, 2023)Sjogren's syndrome (SS) is a chronic autoimmune connective tissue disease. Varying rates of system involvements may be seen in the course of the disease. Semaphorins has multifunctions in several physiological and ... -
Best Practices of Feature Selection in Multi-Omics Data
Halef Okan Dogan (IGI Global, 2023)Today, there is an increase in data in many areas. With this increase, the number and variety of the variables to be evaluated also increases. The increase in data and variables became a situation that needed to be solved ... -
Increased endoplasmic reticulum stress might be related to brain damage in hepatic ischemia-reperfusion injury
Halef Okan Dogan (2023)Objectives: Our study aimed to investigate the role of endoplasmic reticulum stress (ER) in brain damage following hepatic ischemia-reperfusion (HIR) injury. Specifically, we characterized the expression of markers of ... -
Mide Kanser ve Omik Tabanlı Analizler
Çoğu normal doku hücresiyle karşılaştırıldığında kanser hücrelerinde belirgin olarak farklı metabolik yolaklarda değişiklikler görülür. Omik tabanlı veri entegrasyonu, mide kanseri araştırmalarında kapsamlı bir şekilde ... -
Mitochondrial Homeostasis and Mast Cells in Experimental Hepatic Ischemia-Reperfusion Injury of Rats.
Background: Ischemia-reperfusion injury is a histopathological event and is an important cause of morbidity and mortality after hepatobiliary surgery. We aimed to investigate the protective effect of uridine on hepatic ... -
MİDE KANSERİ VE DENEY HAYVANLARI MODELLEMELERİ
Mide karsinogeneziyle ilgili çalışmalar için çeşitli mide fenotiplerine sahip çok sayıda hayvan modeli mevcuttur. Mide kanseriyle ilgili mekanizmaları anlamak, önleyici ve terapötik müdahaleler tasarlamak için hayvan ... -
The use of laboratory parameters and computed tomography score to determine intensive care unit requirement in COVID-19
Halef Okan Dogan; Serkan Bolat; Seyit A Büyüktuna; Rağıp Sarıismailoğlu; Nazım Çetinkaya; Kübra Doğan; Mürşit Hasbek; Halil Caylak (2021)Objectives It is vital to determine the intensive care unit (ICU) requirement at an early stage to reduce the mortality rate in COVID-19 patients. The aim of the study was to find reliable predictive markers to determine ... -
Understanding the pathophysiological changes via untargeted metabolomics in COVID‐19 patients
Halef Okan Dogan; onur şenol; Serkan Bolat; Şeyma N Yıldız; Seyit A Büyüktuna; Rağıp Sarıismailoğlu; Kübra Doğan; Mürşit Hasbek; Süleyman N Hekim (Wiley, 2021 Nisan)Coronavirus disease 2019 (COVID-19) is an infectious respiratory disease caused by a new strain of the coronavirus. There is limited data on the pathogenesis and the cellular responses of COVID-19. In this study, we aimed ... -
Validation of Friedewald, Martin-Hopkins and Sampson low-density lipoprotein cholesterol equations
Gözde Ertürk Zararsız; Serkan Bolat; Ahu Cephe; Necla Kochan; Serra İlayda Yerlitaş; Halef Okan Doğan; Gökmen Zararsız (2022/5/13)Background: Low-density lipoprotein cholesterol (LDL-C) is an important biomarker for determining cardiovascular risk and regulating lipid lowering therapy. Therefore, the accurate estimation of LDL-C concentration is ... -
Validation of low-density lipoprotein cholesterol equations in pediatric population
Halef Okan Dogan (2023)Several studies have shown a high prevalence of dyslipidemia in children. Since childhood lipid concentrations continue into adulthood, recognition of lipid abnormalities in the early period is crucial to prevent the ...