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Metformin prevents morphine‑induced apoptosis in rats with diabetic neuropathy: a possible mechanism for attenuating morphine tolerance
(Springer, 2022)
Morphine is a drug of choice for the treatment of severe and chronic pain, but tolerance to the antinociceptive efect limits its use. The development of tolerance to morphine has recently been associated with neuronal ...
Evaluation of the Effect of Interscalene Brachial Plexus Block on Intracranial Pressure Using Optic Nerve Sheath Diameter and Internal Jugular vein Collapsibility Index
(Journal of the College of Physicians and Surgeons Pakistan, 2022)
Objective: To determine the effect of single-shot interscalene brachial plexus (ISBP) block on intracranial pressure (ICP) by eval uating the extravascular volume effect of the medicine on the internal jugular vein ...
Relationship between Systemic Immune-inflammation Index and Mortality in Intensive Care Patients Diagnosed with Crimean-Congo Hemorrhagic Fever
(Journal of the College of Physicians and Surgeons Pakistan, 2022)
Objective: To evaluate the power of the systemic immune-inflammation index in the prediction of mortality in severe Crimean--Congo hemorrhagic fever patients.
Study Design: Observational study.
Place and Duration of ...
Galium aparine L. protects against acetaminophen-induced hepatotoxicity in rats
(Elsevier, 2022)
The toxicity of acetaminophen (N-acetyl-para-aminophenol (APAP)) is the most frequent cause of drug-induced liver damage. Galium aparine L. (GA) is traditionally used to treat jaundice. We aimed to investigate the ...
Investigation of the mechanisms involved in anticancer effect of glucosamine sulfate on SH-SY5Y cell line
(Bratislavske lekarske listy, 2022)
Aim: Glucosamine derivatives have been found to have anticancer effects in many cancer cell lines in previous investigations. The effect of glucosamine sulfate on neuroblastoma, however, is uncertain. The potential cytotoxic ...
Death receptor-dependent apoptosis and cell cycle delay induced by bioymifi in human cervical cancer cells
(2022)
Abstract: In chemotherapy applied against cervical cancer, non-specific cytotoxicity and drug resistance that develops
over time are trying to be overcome. Therefore, the development of effective and innovative chemotherapeutic ...
Synthesis, computational analyses, antibacterial and antibiofilm properties of nicotinamide derivatives
(Ağustos 20)
Newly designed nicotinamide derivatives were synthesized and characterized using spectral techniques (IR, 1H-NMR, 13C-NMR, and MS). Moreover, these compounds are investigated computationally. B3LYP/6–31 + G(d,p) level is ...
The 5-HT7 receptor antagonist SB-269970 alleviates seizure activity and downregulates hippocampal c-Fos expression in pentylenetetrazole-induced kindled rats
(NEUROLOGICAL RESEARCH, 2022)
Objectives: Recently, studies have demonstrated that serotonin type 7 receptors (5-HT7) have conflincting effects on neuronal excitability in different brain regions. However, the effect of 5-HT7 on seizures has not been ...
Captopril exhibits protective effects through anti-inflammatory and anti-apoptotic pathways against hydrogen peroxide-induced oxidative stress in C6 glioma cells
(Metabolic Brain Disease, 2022)
Recent studies have shown that angiotensin-converting enzyme (ACE) inhibitors have reduced oxidative damage in the central nervous system (CNS). Accumulating evidence have also demonstrated that captopril, an ACE inhibitor, ...
Is the 5-factor modified Frailty Index a prognostic marker in geriatric ankle fractures?
(2022)
BACKGROUND: The 5-factor modified Frailty Index (mFI-5), which is the latest version of the Frailty Index, is a tool that calculates
the risk of complications after treatment by scoring the comorbidity status of the ...