Effect of adding dexmedetomidine to intra-articular levobupivacaine on postoperative pain following arthroscopic meniscus surgery: A prospective, double-blind, randomized, placebo- controlled, clinical trial
Date
2021Metadata
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Avcı, O. ; Özdemir Kol, İ. of Anesthesiology and Reanimation, Cumhuriyet University, School of Medicine, Sivas, Turkey Gündoğdu, O. ; Erşan, İ. of Anesthesiology and Reanimation, Numune Hospital, Sivas, Turkey Öztemur, Z. Department of Orthopedics and Traumatology, Cumhuriyet University, School of Medicine, Sivas, TurkeyAbstract
Objective: The aim of this study was to determine the effect of adding dexmedetomidine to intra-articular levobupivacaine on
postoperative pain levels and analgesic requirements following arthroscopic meniscectomy.
Methods: A total of 60 American Society of Anesthesiologist physical status I-II patients, aged 20 to 62 years, and scheduled for
arthroscopic partial meniscectomy under general anesthesia were included in this study. All the patients were randomly
assigned to one of four groups (15 patients in each group): Group 1 (8 male, 7 female; mean age = 46.70 ± 13.13 years; 0.9%
isotonic 20 ml), group 2 (7 male, 8 female; mean age = 42.60 ± 12.18 years; levobupivacaine 0.5 mg/kg plus 0.9% isotonic), group 3
(8 male, 7 female; mean age = 43.80 ± 12.63 years; 1μg/kg dexmedetomidine plus 0.9% isotonic), and group 4 (7 female, 8 male;
mean age = 40.40 ± 11.79 years; levobupivacaine 0.5 mg/kg plus 1μg/kg dexmedetomidine and 0.9% isotonic). All medications
were administered at the end of arthroscopic surgery. Pain levels were measured using a Visual Analogous Scale (VAS) and
Verbal Rating Scale (VRS) at postoperative 1, 2, 4, 6, 12, and 24 hours.
Results: VAS scores at rest were significantly lower in Group 4 at postoperative 1th, 2nd, 4th, 6th,12th, and 24th hours than in other
groups. The time to take the first analgesic was significantly higher in Group4 (964 ± 288 min), and total analgesic consumption
was significantly lower in Group 4 compared to those of other groups.
Conclusion: Although administration of intra-articular dexmedetomidine alone may have a weaker effect than intra-articular
levobupivacaine on postoperative pain relief after arthroscopic partial meniscectomy, adding dexmedetomidine to intra-articular
levobupivacaine may increase the durationand quality of postoperative analgesia without any side effect.