| dc.contributor.author | Keklikcioğlu Çakmak, Neşe | |
| dc.contributor.author | N. Khalilov, Ali | |
| dc.contributor.author | Tüzün, Burak | |
| dc.contributor.author | Taslimi, Parham | |
| dc.contributor.author | Taş, Ayça | |
| dc.contributor.author | Tuncbilek, Zuhal | |
| dc.date.accessioned | 2022-05-12T08:32:53Z | |
| dc.date.available | 2022-05-12T08:32:53Z | |
| dc.date.issued | 09.10.2021 | tr |
| dc.identifier.citation | Ali N. Khalilov
; Burak, Tüzün
; Parham, Taslimi
; Ayca, Tas
; Zuhal, Tuncbilek
Nese Keklikcioglu Cakmak
Organic Chemistry Department, Baku State University, Z. Khalilov Str. 23, Az 1148 Baku, Azerbaijan
‘‘Composite Materials‘‘ Scientific Research Center, Azerbaijan State Economic University (UNEC), H. Aliyev Str. 135, Az 1063 Baku, Azerbaijan
Plant and Animal Production Department, Technical Sciences Vocational School of Sivas, Sivas Cumhuriyet University, Sivas, Turkey
dDepartment of Biotechnology, Faculty of Science, Bartin University, 74100 Bartin, Turkey
Department of Chemistry, Faculty of Science, Istinye University, Istanbul, Turkey
Department of Nutrition and Diet, Faculty of Health Sciences, Sivas Cumhuriyet University, Sivas, Turkey
Department of Biochemistry, Faculty of Medicine, Sivas Cumhuriyet University, Sivas, Turkey
Department of Chemical Engineering, Faculty of Engineering, Sivas Cumhuriyet University, Sivas, 58140, Turkey | tr |
| dc.identifier.uri | https://hdl.handle.net/20.500.12418/12888 | |
| dc.description.abstract | b-Amino alcohols (2–4) used in this study were re-synthesized in accordance with our previous study. All
compounds were characterized by the combination of NMR, UV–Vis, IR experimental and theoretical
spectral data. Then, the cytotoxic activity studies of the molecules on SH-SY5Y and L-929 cell lines
showed that compound 2 has the highest activity on SH-SY5Y cells. Afterwards, the inhibition properties
of these derivatives were tested toward acetylcholinesterase (AChE) and a-Glycosidase (a-Gly) enzymes.
The studied molecules were optimized on B3LYP, HF, M062X level 3–21 g, 6–31 g, and SDD basis sets.
Molecular docking calculations were made to determine the biological activity values of the amino alcohols
against the enzymes. Finally, the drug properties of molecules were investigated by ADME/T
analysis | tr |
| dc.description.sponsorship | This work is supported by the Baku State University and Scientific Research Project Fund of Sivas Cumhuriyet University under the project number RGD-020. | tr |
| dc.language.iso | eng | tr |
| dc.publisher | Elsevier | tr |
| dc.relation.isversionof | 10.1016/j.molliq.2021.117761 | tr |
| dc.rights | info:eu-repo/semantics/closedAccess | tr |
| dc.subject | b-Amino alcohols MTT DFT Molecular docking Enzyme Cell culture | tr |
| dc.title | Cytotoxic effect, spectroscopy, DFT, enzyme inhibition, and moleculer docking studies of some novel mesitylaminopropanols: Antidiabetic and anticholinergics and anticancer potentials | tr |
| dc.type | article | tr |
| dc.relation.journal | Journal of Molecular Liquids | tr |
| dc.contributor.department | Mühendislik Fakültesi | tr |
| dc.contributor.authorID | 0000-0002-8634-9232 | tr |
| dc.identifier.volume | 344 | tr |
| dc.identifier.issue | 117761 | tr |
| dc.identifier.endpage | 13 | tr |
| dc.identifier.startpage | 1 | tr |
| dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |
