Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes
Citation
Şahin, N., Üstün, E., Tutar, U., Çelik, C., Gürbüz, N., & Özdemir, İ. (2021). Antimicrobial activity, inhibition of biofilm formation, and molecular docking study of novel Ag-NHC complexes. Journal of Organometallic Chemistry, 954, 122082.Abstract
In this study, we reported the synthesis of a new series of Silver(I)-N-heterocyclic carbene complexes
which were obtained from the corresponding new N-heterocyclic carbene (NHC) precursors. All new
compounds were characterized by elemental analysis, FT-IR, LC-MS, 1H NMR, and 13C{1H} NMR spec-
troscopy. These new N-heterocyclic carbene precursors and Ag(I)-NHC complexes were evaluated for their
antibacterial, antifungal, and antibiofilm activities. The biological activities of synthesized products were
compared with standard drugs. All compounds have moderate antibacterial and antibiofilm activities. In
particular, while compound 2a was found to be the best inhibitor of E. coli biofilms, while compound
2d inhibited C. albicans biofilm at the highest rate. All the compounds were also analyzed by molecular
docking methods with the certain target molecules.
Volume
954Issue
122082URI
https://www.sciencedirect.com/science/article/pii/S0022328X21004034https://hdl.handle.net/20.500.12418/12977