dc.contributor.author | Şahin, Neslihan | |
dc.contributor.author | Üstün, Elvan | |
dc.contributor.author | Çelik, Cem | |
dc.contributor.author | Tutar, Uğur | |
dc.contributor.author | Özdemir, Namık | |
dc.contributor.author | Gürbüz, Nevin | |
dc.contributor.author | Özdemir, İsmail | |
dc.date.accessioned | 2022-05-13T07:51:25Z | |
dc.date.available | 2022-05-13T07:51:25Z | |
dc.date.issued | 2021 | tr |
dc.identifier.citation | Üstün, E., Şahin, N., Çelik, C., Tutar, U., Özdemir, N., Gürbüz, N., & Özdemir, İ. (2021). Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes. Dalton Transactions, 50(42), 15400-15412. | tr |
dc.identifier.uri | https://pubs.rsc.org/en/content/articlelanding/2021/dt/d1dt02003j/unauth | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/12979 | |
dc.description.abstract | Microorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host
cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals.
Inhibition of formation of biofilms through hindering of quorum sensing could be a method for the production
of new generation antibiotics. In this study, four new benzimidazole type NHC precursors (1-allyl-
3-benzyl-5,6-dimethylbenzimidazolium chloride, 1-allyl-3-(2,4,6-trimethylbenzyl)-5,6-dimethylbenzimidazolium
chloride, 1-allyl-3-(2,3,5,6-tetramethylbenzyl)-5,6-dimethylbenzimidazolium chloride,
and 1-allyl-3-(2,3,4,5,6-pentamethylbenzyl)-5,6-dimethylbenzimidazolium chloride and Ag-NHC complexes
of these molecules were synthesized and characterized by elemental analysis, FT-IR spectroscopy,
1H, and 13C{1H} NMR spectroscopy, LC-MS, and single crystal crystallography. Antimicrobial and biofilm
formation inhibition activities of the molecules were evaluated. In addition, the activities of the molecules
were examined in detail by molecular docking analysis. According to the results obtained, higher activity
was achieved with the complex molecules when compared with the benzimidazole derivative ligands. | tr |
dc.language.iso | eng | tr |
dc.relation.isversionof | 10.1039/d1dt02003j | tr |
dc.rights | info:eu-repo/semantics/closedAccess | tr |
dc.subject | N-heterocyclic carbene | tr |
dc.subject | benzimidazole | tr |
dc.subject | antibiofilm activity | tr |
dc.title | Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes | tr |
dc.type | article | tr |
dc.relation.journal | Dalton Transactions | tr |
dc.contributor.department | Eğitim Fakültesi | tr |
dc.contributor.authorID | 0000-0003-1498-4170 | tr |
dc.identifier.volume | 50 | tr |
dc.identifier.issue | 42 | tr |
dc.identifier.endpage | 15412 | tr |
dc.identifier.startpage | 15400 | tr |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |