Show simple item record

dc.contributor.authorŞahin, Neslihan
dc.contributor.authorÜstün, Elvan
dc.contributor.authorÇelik, Cem
dc.contributor.authorTutar, Uğur
dc.contributor.authorÖzdemir, Namık
dc.contributor.authorGürbüz, Nevin
dc.contributor.authorÖzdemir, İsmail
dc.date.accessioned2022-05-13T07:51:25Z
dc.date.available2022-05-13T07:51:25Z
dc.date.issued2021tr
dc.identifier.citationÜstün, E., Şahin, N., Çelik, C., Tutar, U., Özdemir, N., Gürbüz, N., & Özdemir, İ. (2021). Synthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexes. Dalton Transactions, 50(42), 15400-15412.tr
dc.identifier.urihttps://pubs.rsc.org/en/content/articlelanding/2021/dt/d1dt02003j/unauth
dc.identifier.urihttps://hdl.handle.net/20.500.12418/12979
dc.description.abstractMicroorganisms attach to surfaces and interfaces and form biofilms which create a sheltered area for host cell response. Therefore, biofilms provide troubles in fields such as medicine, food, and pharmaceuticals. Inhibition of formation of biofilms through hindering of quorum sensing could be a method for the production of new generation antibiotics. In this study, four new benzimidazole type NHC precursors (1-allyl- 3-benzyl-5,6-dimethylbenzimidazolium chloride, 1-allyl-3-(2,4,6-trimethylbenzyl)-5,6-dimethylbenzimidazolium chloride, 1-allyl-3-(2,3,5,6-tetramethylbenzyl)-5,6-dimethylbenzimidazolium chloride, and 1-allyl-3-(2,3,4,5,6-pentamethylbenzyl)-5,6-dimethylbenzimidazolium chloride and Ag-NHC complexes of these molecules were synthesized and characterized by elemental analysis, FT-IR spectroscopy, 1H, and 13C{1H} NMR spectroscopy, LC-MS, and single crystal crystallography. Antimicrobial and biofilm formation inhibition activities of the molecules were evaluated. In addition, the activities of the molecules were examined in detail by molecular docking analysis. According to the results obtained, higher activity was achieved with the complex molecules when compared with the benzimidazole derivative ligands.tr
dc.language.isoengtr
dc.relation.isversionof10.1039/d1dt02003jtr
dc.rightsinfo:eu-repo/semantics/closedAccesstr
dc.subjectN-heterocyclic carbenetr
dc.subjectbenzimidazoletr
dc.subjectantibiofilm activitytr
dc.titleSynthesis, characterization, antimicrobial and antibiofilm activity, and molecular docking analysis of NHC precursors and their Ag-NHC complexestr
dc.typearticletr
dc.relation.journalDalton Transactionstr
dc.contributor.departmentEğitim Fakültesitr
dc.contributor.authorID0000-0003-1498-4170tr
dc.identifier.volume50tr
dc.identifier.issue42tr
dc.identifier.endpage15412tr
dc.identifier.startpage15400tr
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıtr


Files in this item

This item appears in the following Collection(s)

Show simple item record