dc.contributor.author | Üstün, Elvan | |
dc.contributor.author | Özdemir, Namık | |
dc.contributor.author | Şahin, Neslihan | |
dc.date.accessioned | 2022-05-13T07:53:34Z | |
dc.date.available | 2022-05-13T07:53:34Z | |
dc.date.issued | 2021 | tr |
dc.identifier.citation | Üstün, E., Özdemir, N., & Şahin, N. (2022). Activity analysis of new N-heterocyclic carbenes and silver N-heterocyclic carbene molecules against novel coronavirus by UV-vis, fluorescence spectroscopy and molecular docking. Journal of Coordination Chemistry, 1-18. | tr |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/00958972.2022.2026935?casa_token=haTHMRArgrgAAAAA%3AQvkBDpkeQEJo20UtmgPR-eWkgq92GWydDwcN4DvjOdq8KhT2vMzTnDLqi9s4rcKqwKYd0-VXXVfkbpk | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/12980 | |
dc.description.abstract | The biggest pandemic that this generation has experienced is still
continuing. While researchers concentrated on vaccine studies,
development of treatment procedures and anti-viral drugs are
other important parts of struggle against Severe Acute
Respiratory Syndrome Coronavirus-2. Also, N-heterocyclic carbenes
and their metal complexes have been studied recently as prodrug
researches. In this study, complexation and binding behavior
of N-heterocyclic carbene precursor and its silver complex with
Bovine Serum Albumin were analyzed by UV-vis and fluorescence
spectroscopy. The binding constant of the silver N-heterocyclic
carbene complex was determined as 1.38(±0.82) 106 M 1, and
the number of binding sites was also determined as 1.2. The
structural, Frontier orbital, and electronic transition analyses were
performed by Density Functional Theory/Time-Dependent Density
Functional Theory. In addition, docking of the molecules in two
different Severe Acute Respiratory Syndrome Coronavirus-2 crystal
structures and also in Bovine Serum Albumin crystal structure
were carried out with the molecular docking method, which is
accepted as an essential tool in pharmaceutical studies. According
to the docking results, the interactions of N-heterocyclic carbene
and its silver complex are better than studied antiviral drugs, and
silver complex has better results than that of precursor | tr |
dc.language.iso | eng | tr |
dc.relation.isversionof | 10.1080/00958972.2022.2026935 | tr |
dc.rights | info:eu-repo/semantics/closedAccess | tr |
dc.subject | N-heterocyclic carbene | tr |
dc.subject | Silver complexes | tr |
dc.subject | Covid-19 | tr |
dc.subject | Molecular docking | tr |
dc.subject | BSA binding | tr |
dc.title | Activity analysis of new N-heterocyclic carbenes and silver N-heterocyclic carbene molecules against novel coronavirus by UV-vis, fluorescence spectroscopy and molecular docking | tr |
dc.type | article | tr |
dc.relation.journal | Journal of Coordination Chemistry | tr |
dc.contributor.department | Eğitim Fakültesi | tr |
dc.contributor.authorID | 0000-0003-1498-4170 | tr |
dc.identifier.volume | 74 | tr |
dc.identifier.issue | 21-24 | tr |
dc.identifier.endpage | 3126 | tr |
dc.identifier.startpage | 3109 | tr |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |