dc.contributor.author | Tüzün, B | |
dc.contributor.author | Gedikli, Mustafa Asım | |
dc.contributor.author | Tüzün, Burak | |
dc.contributor.author | Aktaş, Ahmet | |
dc.contributor.author | Sayın, Koray | |
dc.contributor.author | Ataseven, Hilmi | |
dc.date.accessioned | 2022-05-13T08:17:27Z | |
dc.date.available | 2022-05-13T08:17:27Z | |
dc.date.issued | 2021 | tr |
dc.identifier.citation | Gedikli MA1, Tuzun B2, Aktas A1, Sayin K2,3, Ataseven H4
Sivas Cumhuriyet University, Faculty of Science, Department of Chemistry, Sivas, Turkey | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/12992 | |
dc.description.abstract | BACKGROUND: SARS-CoV-2, which started in Wuhan and later affected the whole world, is the most
important disease of the world today. Many ways to inhibit SARS-CoV-2 virus are sought to prevent the
spread of this virus. Azithromycin and clarithromycin are considered for the treatment of the SARS-CoV-2
virus, which has a high similarity to previous colonic diseases.
AIM: We aimed to determine whether azithromycin and clarithromycin, the RNA-dependent RNA polymerase
protein inhibitor used in the treatment of COVID-19, is effective against SARS Cov-2 in silico.
RESULTS AND CONCLUSION: The 503 analogues of azithromycin and clarithromycin were studied to target
SARS-CoV-2 the RNA-dependent RNA polymerase protein inhibition. Maestro program was used to compare
the inhibition activities of these analogues. A detailed comparison was made using the numerical value of
many parameters obtained. ADME / T properties were then examined to determine the effects and reactions
of analogues on human metabolism. In this study, the SARS-CoV2 virus is 6NUR and 6NUS, which is the
RNA-dependent RNA polymerase protein. Among these proteins, the best inhibitor among the 503 analogues
according to the docking score parameter was 9851445 with a great difference. This analogue was an
analogue of azithromycin (Tab. 3, Fig. 6, Ref. 58). | tr |
dc.language.iso | eng | tr |
dc.rights | info:eu-repo/semantics/restrictedAccess | tr |
dc.subject | SARS-CoV-2 | tr |
dc.subject | RNA-dependent RNA polymerase | tr |
dc.subject | Azithromycin, Clarithromycin | tr |
dc.subject | COVID19 | tr |
dc.title | Are clarithromycin, azithromycin and their analogues effective in the treatment of COVID19? | tr |
dc.type | article | tr |
dc.contributor.department | Eğitim Bilimleri Enstitüsü | tr |
dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |