Carbazole derivatives: Synthesis, spectroscopic characterization, antioxidant activity, molecular docking study, and the quantum chemical calculations
Abstract
A various carbazole derivativeswere synthesized for the synthesis 2,3-Dihydro-1H-carbazol-4(9H)-one O-acetyl
oxime (3), ethyl 2-(2,3,4,9-tetrahydrospiro[carbazole-1,2 -[1,3]dithiolane]-2-yl)acetate (5), 2- hydroxyethyl
{2,3,4,9-tetrahydrospiro[1H-carbazole-1,2 [1,3]dithiolane-4-one]-2-yl}-acetamide (7). These products (3, 5,
and 7) were characterized by the spectroscopic techniques (IR, 1H NMR, 13C NMR and elemental analysis).
Then, the observed FT-IR and NMR peaks of the studied compounds were compared with the calculated values.
The FMO analyses disclosed that the (5) would prefer intermolecular interactions more than intramolecular interactions
because of its higher energy gap. NBO analyses displayed that the n * and * interactionswere
responsible for the lowering of the stabilization energy. The molecular docking studies showed that (5) exhibited
highest binding af nitywith the human glutathione reductase at binding site (−7.21 kcal/mol). Also, the antioxidant
activities were investigated using the CUPRAC method, and TEAC coef cient implied that compound (3)
have an antioxidant property. In addition, docking calculations of the compound (3), (5), and(7)were performed
on bacterial tyrosinase enzyme and human glutathione reductase protein
URI
https://www.sciencedirect.com/science/article/pii/S0167732221003767https://hdl.handle.net/20.500.12418/13022