dc.contributor.author | Aydın, Ali | |
dc.contributor.author | Ökten, Salih | |
dc.contributor.author | Erkan, Sultan | |
dc.contributor.author | Bulut, Merve | |
dc.contributor.author | Özcan, Evrencan | |
dc.contributor.author | Tutar, Ahmet | |
dc.contributor.author | Eren, Tamer | |
dc.date.accessioned | 2022-05-13T11:14:51Z | |
dc.date.available | 2022-05-13T11:14:51Z | |
dc.date.issued | nisan 2021 | tr |
dc.identifier.citation | Ali Aydın,[a]SalihÖkten,*[b]SultanErkan,[c]MerveBulut,[d]EvrencanÖzcan,[d]AhmetTutar,[e]and TamerEren[d
[a]Assoc.Prof. Dr. A. AydınDepartmentof BasicMedicalScience,Facultyof Medicine,BozokUniversity,Yozgat,Turkey
[b]Assoc.Prof. Dr. S. ÖktenDepartmentof Mathsand ScienceEducation,Facultyof Education,KırıkkaleUniversity,Yahşihan,Kırıkkale,TurkeyE-mail:sokten@gmail.comsalihokten@kku.edu.tr
[c]Dr. SultanErkanDepartmentof Chemistry,Facultyof Science,SivasCumhuriyetUniversity,Sivas,Turkey
[d]M. Sc. M. Bulut,Assoc.Prof. Dr. E. Özcan,Prof. Dr. T. ErenDepartmentof IndustrialEngineering,Facultyof Engineeringand Architecture,KırıkkaleUniversity,Yahşihan,Kırıkkale,Turkey
[e]Prof. Dr. A. TutarFacultyof Art and Science,Departmentof Chemistry,SakaryaUniversity,Serdivan,Sakarya,Turkey | tr |
dc.identifier.uri | https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.202004753 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/13044 | |
dc.description.abstract | The present study describes mono substituted indeno[1,2-b]quinolines (3 a–c and 5) have much more antiproliferative potentials than positive controls against A549, HeLa, MCF7 and Hep3B cell lines (IC50 values 1.1–29.6 μg/mL) and show similar cytotoxicity (14.3 % to 19.8 %) to cells such as controls. Moreover, the mono substituted indeno[1,2-b]quinoline amines (3 a–c and 5) exhibit significant antimicrobial activity with MIC values between 15.62 μg/mL and 250 μg/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1×103–1.1×105 M−1. The anticancer and antibacterial properties of compounds were confirmed with the molecular docking simulation for their pharmacokinetic. As a result, the preliminary experimental data and a multi-criteria decision-making methodology (MCDM) indicated that the mono substituted indeno[1,2-b]quinoline amine derivatives, especially 3 a and 5, exhibit effective pharmacological properties. parameters and their interaction with related cells at the molecular level. | tr |
dc.language.iso | eng | tr |
dc.publisher | chemistry europe | tr |
dc.relation.isversionof | 10.1002/slct.202004753 | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.subject | Antibacterial Activities , Molecular Docking | tr |
dc.title | In–Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2-b]qinoline Amines Supported with Molecular Docking and MCDM | tr |
dc.type | article | tr |
dc.relation.journal | ChemistrySelect | tr |
dc.contributor.department | Fen Fakültesi | tr |
dc.contributor.authorID | 0000-0001-6744-929X | tr |
dc.identifier.volume | 6 | tr |
dc.identifier.endpage | 3295 | tr |
dc.identifier.startpage | 3286 | tr |
dc.relation.publicationcategory | Uluslararası Editör Denetimli Dergide Makale - Başka Kurum Yazarı | tr |