| dc.description.abstract | Lasia spinosa (L.) is used ethnobotanically for the treatment of various diseases, including rheumatoid arthritis, inflammation of
the lungs, bleeding cough, hemorrhoids, intestinal diseases, stomach pain, and uterine cancer. This review is aimed at
summarizing phytochemistry and pharmacological data with their molecular mechanisms of action. A search was performed in
databases such as PubMed, Science Direct, and Google Scholar using the keywords: “Lasia spinosa,” then combined with
“ethnopharmacological use,” “phytochemistry,” and “pharmacological activity.” This updated review included studies with
in vitro, ex vivo, and in vivo experiments with compounds of known concentration and highlighted pharmacological
Hindawi
Oxidative Medicine and Cellular Longevity
Volume 2021, Article ID 1602437, 12 pages
https://doi.org/10.1155/2021/1602437
mechanisms. The research results showed that L. spinosa contains many important nutritional and phytochemical components
such as alkanes, aldehydes, alkaloids, carotenoids, flavonoids, fatty acids, ketones, lignans, phenolics, terpenoids, steroids, and
volatile oil with excellent bioactivity. The importance of this review lies in the fact that scientific pharmacological evidence
supports the fact that the plant has antioxidant, anti-inflammatory, antimicrobial, cytotoxic, antidiarrheal, antihelminthic,
antidiabetic, antihyperlipidemic, and antinociceptive effects, while protecting the gastrointestinal system and reproductive.
Regarding future toxicological and safety data, more research is needed, including studies on human subjects. In light of these
data, L. spinosa can be considered a medicinal plant with effective bioactives for the adjuvant treatment of various diseases in
humans. | tr |
