Therapeutic Potential of Isoflavones with an Emphasis on Daidzein
Künye
Mohammed M. Alshehri , 1 Javad Sharifi-Rad , 2 Jesús Herrera-Bravo , 3,4 Evelyn L. Jara,3 Luis A. Salazar , 4 Dorota Kregiel , 5 Yadav Uprety,6 Muhammad Akram,7 Mehwish Iqbal , 8 Miquel Martorell , 9 Margalida Torrens-Mas,10 Daniel Gabriel Pons , 11 Sevgi Durna Daştan,12,13 Natália Cruz-Martins , 14,15,16 Fethi Ahmet Ozdemir,17 Manoj Kumar , 18 and William C. Cho 19 1 Pharmaceutical Care Department, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia 2 Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3 Departamento de Ciencias Básicas, Facultad de Ciencias, Universidad Santo Tomas, Chile 4 Center of Molecular Biology and Pharmacogenetics, Scientific and Technological Bioresource Nucleus, Universidad de La Frontera, Temuco 4811230, Chile 5 Department of Environmental Biotechnology, Lodz University of Technology, Wolczanska 171/173, 90-924 Lodz, Poland 6 Amrit Campus, Tribhuvan University, Kathmandu, Nepal 7 Department of Eastern Medicine and Surgery, Directorate of Medical Sciences, GC University Faisalabad, Pakistan 8 Institute of Health Management, Dow University of Health Sciences, Karachi, Pakistan 9 Department of Nutrition and Dietetics, Faculty of Pharmacy and Centre for Healthy Living, University of Concepción, 4070386 Concepción, Chile 10Translational Research In Aging and Longevity (TRIAL Group), Health Research Institute of the Balearic Islands (IdISBA), 07122 Palma, Spain 11Grupo Multidisciplinar de Oncología Traslacional (GMOT), Institut Universitari d’Investigació en Ciències de la Salut (IUNICS), Universitat de les Illes Balears (UIB), Instituto de Investigación Sanitaria Illes Balears (IdISBa), 07122 Palma, Spain 12Department of Biology, Faculty of Science, Sivas Cumhuriyet University, 58140 Sivas, Turkey 13Beekeeping Development Application and Research Center, Sivas Cumhuriyet University, 58140 Sivas, Turkey 14Faculty of Medicine, University of Porto, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal 15Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal 16Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, 4585- 116 Gandra, PRD, Portugal 17Department of Molecular Biology and Genetics, Faculty of Science and Art, Bingol University, Bingol 1200, Turkey 18Chemical and Biochemical Processing Division, ICAR–Central Institute for Research on Cotton Technology, Mumbai 400019, India 19Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong KongÖzet
analogous to mammalian estrogens, and it could be useful with a dual-directional purpose by substituting/hindering with
Hindawi
Oxidative Medicine and Cellular Longevity
Volume 2021, Article ID 6331630, 15 pages
https://doi.org/10.1155/2021/6331630
estrogen and estrogen receptor (ER) complex. Hence, daidzein puts forth shielding effects against a great number of diseases,
especially those associated with the control of estrogen, such as breast cancer, diabetes, osteoporosis, and cardiovascular
disease. However, daidzein also has other ER-independent biological activities, such as oxidative damage reduction acting
as an antioxidant, immune regulator as an anti-inflammatory agent, and apoptosis regulation, directly linked to its
potential anticancer effects. In this sense, the present review is aimed at providing a deepen analysis of daidzein
pharmacodynamics and its implications in human health, from its best-known effects alleviating postmenopausal symptoms
to its potential anticancer and antiaging properties.
