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Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma

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Date

2021

Author

Durna Daştan, Sevgi
jain, divya
Murti, Yogesh
Khan, Vasi Ullah
hossain, rajib
hossain, MOhammed Nabil
Agraval, Krish Kumar
Ashraf, Rana Azem
Islam, Muhammed toregul
Janmeda, Pracheta
tahari, yasaman
Al-shehri, Mohammed
Yeskaliyeva, balakyz
Kıpchakheyeva, aliyeva
Rad, Javad sharifi
Cho, William c

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Abstract

Hepatocellular carcinoma (HCC) is due to poor prognosis and lack of availability of effective treatment. Novel therapeutic strategies will be the fine tuning of intracellular ROS signaling to effectively deprive cells of ROS-induced tumor-promoting events. This review discusses the generation of ROS, the major signaling their modulation in therapeutics. We explore some of the major pathways involved in HCC, which include the VEGF, MAPK/ERK, mTOR, FGF, and Ser/Thr kinase pathways. In this review, we study cornerstone on natural bioactive compounds with their effect on hepatocarcinomas. Furthermore, we focus on oxidative stress and FDA-approved signaling pathway inhibitors, along with chemotherapy and radiotherapy enhancers which with early evidence of success. While more in vivo testing is required to confirm the findings presented here, our findings will aid future nonclinical, preclinical, and clinical studies with these compounds, as well as inspire medicinal chemistry scientists to conduct appropriate research on this promising natural compound and their derivatives.

Source

Oxidative Medicine and Cellular Longevity

URI

https://hdl.handle.net/20.500.12418/13101

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  • Biyoloji Bölümü Makale Koleksiyonu [14]



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