Michael/Michael Addition Cascade of 2-Benzylidene-1- indanones with Chalcones: Synthesis and Biological Evaluations of Novel Polycyclic Compounds
Date
2021Metadata
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Hayreddin Gezegen,*[a] Uğur Tutar,[b] Ceylan Hepokur,[c] Gamze Tüzün,[c] Zeliha Atioğlu,[d] and Mehmet Akkurt[e] This work is dedicated to the memory of Professor İsmail Çelik (1961–2019), lecturer of Sivas Cumhuriyet UniversityAbstract
A series of novel racemic 2-aryloyl-1,3-diaryl-2,3,3a,8a-tetrahy drocyclopenta[a]inden-8(1H)-one derivatives were synthesized
from KOtBu mediated Michael/Michael addition reaction of 2-
benzylidene-1-indanones with chalcones in high yields. This
method provides an efficient route for the synthesis of a new
class of polycyclic compounds have five stereo centers. The
obtained polycyclic compounds were evaluated for the anti microbial and anticancer activities against fifteen microorgan ism and three cell lines. The compound 3r have the best
activity value against the cells (MCF-7 IC50=18.01�0.39 μg/
mL) (MDA-MB- 231 IC50=18.78�1.75 μg/mL) (MCF-10 A IC50=
31.31�0.05 μg/mL).
