An anticancer drug loading and release study to ternary GO-Fe3O4-PPy and Fe3O4 @PPy-NGQDs nanocomposites for photothermal chemotherapy
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Date
2022Author
Atila Dinçer, CerenGetiren, Bengü
Gökalp, Ceren
Çıplak, Zafer
Karakeçili, Ayşe
Yıldız, Nuray
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Photothermal therapy (PTT) is a new treatment method being developed against traditional cancer therapy
methods. In this study, graphene oxide-iron oxide-polypyrrole (GO-Fe3O4-PPy) and iron oxide@polypyrrolenitrogen
doped graphene quantum dots (Fe3O4 @PPy-NGQDs) ternary nanocomposites having superior photothermal
and magnetic properties were loaded with doxorubicin (DOX) anticancer drug. The loading and release
of the DOX was investigated by UV–visible spectroscopy. At the end of 48 h, the cumulative release of DOX from
GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX at pH 5.5 and pH 7.4 was obtained as 99.55% ± 0.20,
48.87% ± 0.20% and 97.88% ± 0.45, 38.82% ± 0.26, respectively. After a short period of time like 4 h and 8 h,
NIR-triggered release of DOX was increased significantly compared to drug release without NIR. The cytotoxic
effects on the 4T1 mouse breast cancer cells of GO-Fe3O4-PPy/DOX and Fe3O4 @PPy-NGQDs/DOX drug loaded
nanocomposites were determined by MTT test. The increase of DOX release with NIR effect was demonstrated by
both in-vitro cytotoxicity studies and confocal laser microscopy images. In summary, multifunctional GO-Fe3O4-
PPy/DOX and Fe3O4 @PPy-NGQDs/DOX nanocomposites have great potential for photothermal chemotherapy.