Synthesis of Multifunctional Organic Nanoparticles Combining Photodynamic Therapy and Chemotherapeutic Drug Release
Date
2022Author
Fazlı SözmenMerve Küçükoflaz
Mustafa Ergül
Zeynep Deniz Şahin İnan
Yasemin Bozkurt
Dilşad Taydaş
Metadata
Show full item recordAbstract
Cancer is a group of diseases that are caused by uncontrolled proliferation
of cells in various parts of the body and it is one of the most studied diseases worldwide.
Photodynamic therapy (PDT) is a treatment that uses photosensitizers called
photosensitizing agents in addition to light to kill cancer cells. Photosensitizers work
only after they have been activated by certain types of light. PDT contains three basic
components, these are a photosensitizer, visible light and molecular oxygen (3O2).
The efficiency of the therapeutic action is directly related to the property of the photosensitizer.
In this study, chitosan and BODIPY based nanoparticles that were capable of carrying out drug delivery and producing singlet
oxygen (1O2) were synthesized for the first time. For this purpose, organic nanoparticles showed PDT feature were synthesized via the
formation of ionic complexes formed with opposite charged ionic interactions between the synthesized BODIPY derivative (PDT agent)
and chitosan hydrochloride at appropriate pH (pH=6). Later, during the formation of this ionic complex, a chemotherapeutic model drug
(Doxorubicin) was added to the medium and chemotherapeutic drug-loaded chitosan and BODIPY-based nanoparticles were synthesized.
Finally, while drug-free (Y1-Chitosan nanoparticles) and drug-loaded organic nanoparticles (Y1-Chitosan-Dox nanoparticles)
showed very good PDT properties, they were found to be effective on MCF7 cancer cells and less toxic to L929 cells.