| dc.description.abstract | Plants including Rhizoma polgonati, Smilax china, and Trigonella foenum-graecum contain a lot of diosgenin, a steroidal
sapogenin. This bioactive phytochemical has shown high potential and interest in the treatment of various disorders such as
cancer, diabetes, arthritis, asthma, and cardiovascular disease, in addition to being an important starting material for the
preparation of several steroidal drugs in the pharmaceutical industry. This review aims to provide an overview of the in vitro,
in vivo, and clinical studies reporting the diosgenin’s pharmacological effects and to discuss the safety issues. Preclinical studies
have shown promising effects on cancer, neuroprotection, atherosclerosis, asthma, bone health, and other pathologies. Clinical
investigations have demonstrated diosgenin’s nontoxic nature and promising benefits on cognitive function and menopause.
However, further well-designed clinical trials are needed to address the other effects seen in preclinical studies, as well as a
better knowledge of the diosgenin’s safety profile | tr |
