Therapeutic Applications of Curcumin in Diabetes: A Review and Perspective
Abstract
Diabetes is a metabolic disease with multifactorial causes which requires lifelong drug therapy as well as lifestyle changes. There is
now growing scientific evidence to support the effectiveness of the use of herbal supplements in the prevention and control of
diabetes. Curcumin is one of the most studied bioactive components of traditional medicine, but its physicochemical
characteristics are represented by low solubility, poor absorption, and low efficacy. Nanotechnology-based pharmaceutical
formulations can help overcome the problems of reduced bioavailability of curcumin and increase its antidiabetic effects. The
objectives of this review were to review the effects of nanocurcumin on DM and to search for databases such as PubMed/
MEDLINE and ScienceDirect. The results showed that the antidiabetic activity of nanocurcumin is due to complex
pharmacological mechanisms by reducing the characteristic hyperglycemia of DM. In light of thes