Browsing Sivas Teknik Bilimler Meslek Yüksekokulu by Subject "enzyme inhibition"
Now showing items 1-5 of 5
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1,2,3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies
(09.12.2020)In recent years, acetylcholinesterase (AChE) and a-glycosidase (a-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, ... -
Design, synthesis, characterization, biological evaluation, and molecular docking studies of novel 1,2-aminopropanthiols substituted derivatives as selective carbonic anhydrase, acetylcholinesterase and a-glycosidase enzymes inhibitors
(26.08.2020)In the article, various substituted derivatives of 1,2-aminopropanthiol (1a–g) have been prepared by a general and efficientmethod, in one-steps, starting fromavailable thiirane and aromatic amines (aniline, o-toluidine) ... -
Design, synthesis, characterization, biological evaluation, and molecular docking studies of novel 1,2-aminopropanthiols substituted derivatives as selective carbonic anhydrase, acetylcholinesterase and α-glycosidase enzymes inhibitors
(27.08.2020)In the article, various substituted derivatives of 1,2-aminopropanthiol (1a–g) have been prepared by a general and efficientmethod, in one-steps, starting fromavailable thiirane and aromatic amines (aniline, o-toluidine) ... -
Eco-friendly and potential colin esterase enzyme inhibitor agent sulfonyl hydrazone series: Synthesis, Bioactivity Screening, DFT, ADME properties, and Molecular Docking study
(elsevier, 04.04.2023)In this study, new compounds containing the sulfonamide group and having inhibitory activity on cholinesterase enzymes (AChE, BChE) were synthesized. For this purpose, three new sulfonylhydrazone compounds were synthesized ... -
Synthesis and docking calculations of tetrafluoronaphthalene derivatives and their inhibition profiles against some metabolic enzymes
(5 February)Syntheses of tetrahydroepoxy, O‐allylic, O‐prenylic, and O‐propargylic tetrafluoronaphthalene derivatives, starting from 1‐bromo‐2,3,4,5,6‐pentafluorobenzene, are reported here for the first time. The O‐substituted ...