| dc.contributor.author | Taşkın Kafa, Ayşe Hümeyra | |
| dc.contributor.author | Tüzün, Gamze | |
| dc.contributor.author | Güney, Elif | |
| dc.contributor.author | Aslan, Rukiye | |
| dc.contributor.author | Sayın, Koray | |
| dc.contributor.author | Tüzün,Burak | |
| dc.contributor.author | Ataseven, Hilmi | |
| dc.date.accessioned | 2023-06-22T12:04:54Z | |
| dc.date.available | 2023-06-22T12:04:54Z | |
| dc.date.issued | Ağustos 2022 | tr |
| dc.identifier.uri | https://hdl.handle.net/20.500.12418/13965 | |
| dc.description.abstract | Newly designed nicotinamide derivatives were synthesized and characterized using spectral techniques (IR, 1H-NMR, 13C-NMR, and MS). Moreover, these compounds are investigated computationally. B3LYP/6–31 + G(d,p) level is selected as the calculation level in this study. Experimental and calculated IR spectrum were compared to each other. Electronic properties of synthesized compounds are examined using HOMO/LUMO contour plot and MEP maps. Antibacterial activity and antibiofilm properties are investigated experimentally. Additionally, antibacterial properties of studied compounds are investigated by molecular docking analyses. As a result, ND4 was found as the best inhibitor candidate against Enterococcus faecalis. | tr |
| dc.language.iso | eng | tr |
| dc.rights | info:eu-repo/semantics/openAccess | tr |
| dc.title | Synthesis, computational analyses, antibacterial and antibiofilm properties of nicotinamide derivatives | tr |
| dc.type | article | tr |
| dc.contributor.department | Tıp Fakültesi | tr |
| dc.contributor.authorID | 0000-0002-7282-4928 | tr |
| dc.relation.publicationcategory | Uluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanı | tr |
