dc.contributor.author | YARŞILIKAL, GÜLEROĞLU FİLİZ | |
dc.contributor.author | SELVİ, ESRA | |
dc.contributor.author | TURAN, BAKIRCI ISIL | |
dc.contributor.author | Bafalı, Olgu | |
dc.contributor.author | Argun Atalmış, Hatice | |
dc.contributor.author | YASTI DAYAN, MERVE | |
dc.contributor.author | BALKAN, ÖZMEN ALİYE | |
dc.contributor.author | YURTCU, NAZAN | |
dc.contributor.author | Seker Atas, Busra | |
dc.contributor.author | Özdemir Anayurt, Esma | |
dc.contributor.author | ÇETİN, ALİ | |
dc.date.accessioned | 2023-06-23T05:10:27Z | |
dc.date.available | 2023-06-23T05:10:27Z | |
dc.date.issued | 2023/2 | tr |
dc.identifier.citation | Yarsilikal Guleroglu F, Selvi E, Turan Bakirci I, Bafalı O, Argun Atalmis H, Yasti Dayan M, Balkan Ozmen A, Yurtcu N, Seker Atas B, Ozdemir Anayurt E, Cetin A. Clinical Value of Serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 Levels in Pregnant Women with Obesity and the Related Comorbidities Diabetes Mellitus and Gestational Hypertension. Z Geburtshilfe Neonatol. 2023 Feb;227(1):42-50. doi: 10.1055/a-1937-1155. Epub 2022 Sep 28. PMID: 36170878. | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/14003 | |
dc.description.abstract | Aims We evaluated the clinical value of selected serum biomarkers BMP-4, BMP-2, GDF-15, MMP-9, and GP39 in pregnant women with obesity and the comorbidities diabetes mellitus (DM) and gestational hypertension (GHT).
Methods This observational study had groups of controls, including healthy pregnant women; women with only obesity, including pregnant women with BMI≥30 kg/m2; women with gestational DM (GDM) with obesity, including pregnant women with GDM and obesity; women with pregestational DM (PGDM) with obesity, including pregnant women with PGDM and obesity; and women with GHT with obesity, including pregnant women with GHT and obesity. We measured serum levels of selected biomarkers by ELISA.
ResultsObesity increased serum levels of all the biomarkers; GDM developed in obese women caused a more pronounced increase in the serum levels of BMP-4 and BMP-2, and GHT developed in obese women caused a more pronounced increase in the serum levels of GDF-15. In the women with GDM-, PGDM-, and GHT-complicated obesity, serum levels of MMP-9 and GP39 did not change meaningfully.
Conclusions Obesity and its comorbidities DM and GHT lead to meaningful changes in the studied serum biomarkers. Since obesity has a causal effect on developing numerous conditions, reliable clinical biomarkers are needed to improve the early prediction and diagnosis of high-risk conditions during pregnancy. | tr |
dc.language.iso | eng | tr |
dc.relation.isversionof | DOI: 10.1055/a-1937-1155 | tr |
dc.rights | info:eu-repo/semantics/openAccess | tr |
dc.subject | Pregnancy - obesity - diabetes mellitus - gestational hypertension - biomarker | tr |
dc.title | Clinical value of serum BMP-4, BMP-2, GDF-15, MMP-9, GP39 levels in pregnant women with obesity and the related comorbidities diabetes mellitus and gestational hypertension | tr |
dc.type | article | tr |
dc.relation.journal | Zeitschrift für Geburtshilfe und Neonatologie | tr |
dc.contributor.department | Tıp Fakültesi | tr |
dc.contributor.authorID | 0000-0003-4725-043X | tr |
dc.identifier.volume | 227 | tr |
dc.identifier.issue | 01 | tr |
dc.identifier.endpage | 50 | tr |
dc.identifier.startpage | 42 | tr |
dc.relation.publicationcategory | Uluslararası Editör Denetimli Dergide Makale | tr |