dc.contributor.author | Kuzu, Burak | |
dc.contributor.author | HEPOKUR, CEYLAN | |
dc.contributor.author | Türkmenoğlu,Burçin | |
dc.contributor.author | Burmaoğlu,Serdar | |
dc.contributor.author | Algül, öztekin | |
dc.date.accessioned | 2023-06-23T05:18:30Z | |
dc.date.available | 2023-06-23T05:18:30Z | |
dc.date.issued | 2022 | tr |
dc.identifier.uri | https://hdl.handle.net/20.500.12418/14012 | |
dc.description.abstract | Background: Phortress produces reactive electrophilic metabolites that form DNA adducts only in
sensitive tumor cells. The authors converted the 2-phenylbenzothiazole nucleus in phortress to 2-
aryl and -heteroaryl benzoxazole derivatives (11 new and 14 resynthesized). All synthesized
compounds were studied for antitumor activity in various cancer cells. Materials & methods:
Cytotoxicity, cell morphology, flow cytometry and cell-cycle analyses of compounds were
performed and more active derivatives were tested in the MCF-7 cell line. Conclusion: Methyl 2-
(thiophen-2-yl)benzo[d]oxazole-6-carboxylate (BK89) has a higher effect than fluorouracil to
induce apoptotic cell death (apoptosis value of 49.44%). Cell-cycle analysis shows that the
compounds BK89 and methyl 2-(furan-2-yl)benzo[d]oxazole-6-carboxylate (BK82) can be used
as potential cell-cycle blockers by arresting MCF-7 cells in G0/G1 phase at rates of 63% and 85%,
respectively. | tr |
dc.rights | info:eu-repo/semantics/restrictedAccess | tr |
dc.title | Design, synthesis and in vitro antiproliferation activity of some 2-aryl and -heteroaryl benzoxazole derivatives | tr |
dc.type | article | tr |
dc.contributor.department | Eczacılık Fakültesi | tr |
dc.relation.publicationcategory | Rapor | tr |